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SY SY - Synaptic Systems SY SY - Synaptic Systems

TMEM 119

A microglia specific transmembrane protein

References SySy TMEM 119 antibodies

New tools for studying microglia in the mouse and human CNS.
Bennett ML, Bennett FC, Liddelow SA, Ajami B, Zamanian JL, Fernhoff NB, Mulinyawe SB, Bohlen CJ, Adil A, Tucker A, Weissman IL, et al.
Proceedings of the National Academy of Sciences of the United States of America (2016) 11312: E1738-46.
TMEM119 marks a subset of microglia in the human brain.
Satoh J, Kino Y, Asahina N, Takitani M, Miyoshi J, Ishida T, Saito Y
Neuropathology : official journal of the Japanese Society of Neuropathology (2016) 361: 39-49.
Genetically induced brain inflammation by Cnp deletion transiently benefits from microglia depletion.
Garcia-Agudo LF, Janova H, Sendler LE, Arinrad S, Steixner AA, Hassouna I, Balmuth E, Ronnenberg A, Schopf N, van der Flier FJ, Begemann M, et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2019) : fj201900337R. 400 002 IHC; tested species: mouse
Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia.
Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow S, Glatzel M, Krasemann S
Acta neuropathologica communications (2019) 71: 83. 400 002 IHC; tested species: mouse
Microglia pre-activation and neurodegeneration precipitate neuroinflammation without exacerbating tissue injury in experimental autoimmune encephalomyelitis.
Wimmer I, Scharler C, Zrzavy T, Kadowaki T, Mödlagl V, Rojc K, Tröscher AR, Kitic M, Ueda S, Bradl M, Lassmann H, et al.
Acta neuropathologica communications (2019) 71: 14. 400 002 IHC-P; tested species: rat
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com