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SY SY - Synaptic Systems SY SY - Synaptic Systems

Synuclein

A protein involved in Parkinson's and Alzheimer's Disease

References SySy Synuclein antibodies

Genetics of Parkinson's disease.
Polymeropoulos MH
Annals of the New York Academy of Sciences (2000) 920: 28-32.
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment.
Stefanova N, Seppi K, Scherfler C, Puschban Z, Wenning GK
Journal of neural transmission. Supplementum (2000) 60: 335-43.
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease.
Clayton DF, George JM
Trends in neurosciences (1998) 216: 249-54.
Filamentous nerve cell inclusions in neurodegenerative diseases.
Goedert M, Spillantini MG, Davies SW
Current opinion in neurobiology (1998) 85: 619-32.
Genetic classification of primary neurodegenerative disease.
Hardy J, Gwinn-Hardy K
Science (New York, N.Y.) (1998) 2825391: 1075-9.
The synuclein family.
Lavedan C
Genome research (1998) 89: 871-80.
New developments in understanding the etiology of Parkinson's disease and in its treatment.
Lozano AM, Lang AE, Hutchison WD, Dostrovsky JO
Current opinion in neurobiology (1998) 86: 783-90.
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.
Vinueza-Gavilanes R, Íñigo-Marco I, Larrea L, Lasa M, Carte B, Santamaría E, Fernández-Irigoyen J, Bugallo R, Aragón T, Aldabe R, Arrasate M, et al.
Neurobiology of disease (2020) : 104781. 128 211 WB, ICC; tested species: human
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain.
Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ, Brück W
Journal of neurochemistry (2010) 1144: 1007-18. 128 002 WB
Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation.
Tong J, Wong H, Guttman M, Ang LC, Forno LS, Shimadzu M, Rajput AH, Muenter MD, Kish SJ, Hornykiewicz O, Furukawa Y, et al.
Brain : a journal of neurology (2010) 133Pt 1: 172-88. 128 002 WB; tested species: human
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 128 002 WB
alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity.
Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L, Fasano M
Biochemical and biophysical research communications (2006) 3494: 1294-300. 128 002 WB
Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein.
Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, et al.
Molecular and cellular biology (2005) 254: 1339-46. 128 002 WB
Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity.
Jüttner R, Moré MI, Das D, Babich A, Meier J, Henning M, Erdmann B, Mu Ller EC, Otto A, Grantyn R, Rathjen FG, et al.
Neuron (2005) 462: 233-45. 128 102 WB
A broken alpha -helix in folded alpha -Synuclein.
Chandra S, Chen X, Rizo J, Jahn R, Südhof TC
The Journal of biological chemistry (2003) 27817: 15313-8. 128 002 WB
N-terminal acetylation mutants affect alpha-synuclein stability, protein levels and neuronal toxicity.
Vinueza-Gavilanes R, Íñigo-Marco I, Larrea L, Lasa M, Carte B, Santamaría E, Fernández-Irigoyen J, Bugallo R, Aragón T, Aldabe R, Arrasate M, et al.
Neurobiology of disease (2020) : 104781. 128 211 WB, ICC; tested species: human
E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.
Íñigo-Marco I, Valencia M, Larrea L, Bugallo R, Martínez-Goikoetxea M, Zuriguel I, Arrasate M
Proceedings of the National Academy of Sciences of the United States of America (2017) 11439: E8274-E8283. 128 211 ICC; tested species: rat
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 128 002 WB, ICC, IHC; tested species: mouse,rat
Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification.
Cole NB, Dieuliis D, Leo P, Mitchell DC, Nussbaum RL
Experimental cell research (2008) 31410: 2076-89. 128 002 WB, ICC, EM
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Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com