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Synapsin1/2 antibody - 106 004 K.O.

Synapsins are peripheral synaptic vesicle proteins and substrate for several protein kinases
Guinea pig polyclonal antiserum
Cat. No.: 106 004
Amount: 100 µl
Price: $395.00
Cat. No. 106 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 2 to 28 from rat Synapsin1 (UniProt Id: P09951)
Reactivity Reacts with: human (P17600, Q92777), rat (P09951, Q63537), mouse (O88935, Q64332), hamster, cow, zebrafish.
Other species not tested yet.
Specificity Specific for synapsins 1a/b and 2a/b. K.O. validated
Matching control protein/peptide 106-0P
Data sheet 106_004.pdf

References for Synapsin1/2 - 106 004

Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Arias-Hervert ER, Xu N, Njus M, Murphy GG, Hou Y, Williams JA, Lentz SI, Ernst SA, Stuenkel EL
Physiological reports (2020) 89: e14428. 106 004 WB; tested species: mouse
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, et al.
Neurobiology of disease (2019) : . 106 004 WB; tested species: rat
Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells.
Voogd EJHF, Doorn N, Levers MR, Hofmeijer J, Frega M
Journal of neural engineering (2024) 206: . 106 004 ICC; tested species: human
Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis.
Ogunmowo TH, Jing H, Raychaudhuri S, Kusick GF, Imoto Y, Li S, Itoh K, Ma Y, Jafri H, Dalva MB, Chapman ER, et al.
Nature communications (2023) 141: 2888. 106 004 ICC; tested species: mouse
Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter.
Saenz J, Yao O, Khezerlou E, Aggarwal M, Zhou X, Barker DJ, DiCicco-Bloom E, Pan PY
iScience (2023) 261: 105782. 106 004 ICC; tested species: mouse
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.
Wang S, Rhijn JV, Akkouh I, Kogo N, Maas N, Bleeck A, Ortiz IS, Lewerissa E, Wu KM, Schoenmaker C, Djurovic S, et al.
Cell reports (2022) 395: 110790. 106 004 ICC; tested species: human
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.
López-Hernández T, Takenaka KI, Mori Y, Kongpracha P, Nagamori S, Haucke V, Takamori S
eLife (2022) 11: . 106 004 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 106 004 ICC; tested species: human,mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 106 004 ICC; tested species: rat
Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons.
Jorratt P, Ricny J, Leibold C, Ovsepian SV
Molecular neurobiology (2022) : . 106 004 ICC; tested species: mouse
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, et al.
Brain communications (2022) 46: fcac267. 106 004 ICC; tested species: human
A presynaptic phosphosignaling hub for lasting homeostatic plasticity.
Müller JA, Betzin J, Santos-Tejedor J, Mayer A, Oprişoreanu AM, Engholm-Keller K, Paulußen I, Gulakova P, McGovern TD, Gschossman LJ, Schönhense E, et al.
Cell reports (2022) 393: 110696. 106 004 ICC; tested species: mouse
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.
Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, et al.
The Journal of experimental medicine (2021) 2185: . 106 004 ICC; tested species: mouse
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
Salehi MS, Neumann ID, Jurek B, Pandamooz S
International journal of molecular sciences (2021) 2216: . 106 004 ICC; tested species: rat
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Bassil R, Shields K, Granger K, Zein I, Ng S, Chih B
Nature communications (2021) 121: 5220. 106 004 ICC; tested species: human
Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1.2-L1342P genetic variant.
Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 106 004 ICC; tested species: human
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, et al.
Autophagy (2021) : 1-20. 106 004 ICC; tested species: human
Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A
Cellular and molecular life sciences : CMLS (2021) : . 106 004 ICC; tested species: rat
Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips.
Middelkamp HHT, Verboven AHA, De Sá Vivas AG, Schoenmaker C, Klein Gunnewiek TM, Passier R, Albers CA, 't Hoen PAC, Nadif Kasri N, van der Meer AD
Scientific reports (2021) 111: 2281. 106 004 ICC; tested species: human
m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity.
Klein Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman K, Panneman D, Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, et al.
Cell reports (2020) 313: 107538. 106 004 ICC; tested species: human
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 106 004 ICC; tested species: mouse
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J
International journal of molecular sciences (2020) 2112: . 106 004 ICC; tested species: human
Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity.
van Oostrum M, Campbell B, Seng C, Müller M, Tom Dieck S, Hammer J, Pedrioli PGA, Földy C, Tyagarajan SK, Wollscheid B
Nature communications (2020) 111: 4990. 106 004 ICC; tested species: rat
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Cavallo F, Troglio F, Fagà G, Fancelli D, Shyti R, Trattaro S, Zanella M, D'Agostino G, Hughes JM, Cera MR, Pasi M, et al.
Molecular autism (2020) 111: 88. 106 004 ICC; tested species: human
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 106 004 ICC; tested species: human
Loss of Tiparp results in aberrant layering of the cerebral cortex.
Grimaldi G, Vagaska B, Ievglevskyi O, Kondratskaya E, Glover J, Matthews J
eNeuro (2019) : . 106 004 ICC; tested species: mouse
Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons.
Sanford L, Carpenter MC, Palmer AE
Scientific reports (2019) 91: 9411. 106 004 ICC; tested species: rat
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : . 106 004 ICC; tested species: rat
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 106 004 ICC; tested species: mouse
Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse.
Guedes-Dias P, Nirschl JJ, Abreu N, Tokito MK, Janke C, Magiera MM, Holzbaur ELF
Current biology : CB (2018) : . 106 004 ICC; tested species: rat
Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.
Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, Danglot L, Olivo-Marin JC
Nature communications (2018) 91: 698. 106 004 ICC; tested species: mouse
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 106 004 ICC; tested species: mouse
Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice.
Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, Takeichi M
Scientific reports (2017) 71: 5801. 106 004 ICC; tested species: mouse
GLUT4 Mobilization Supports Energetic Demands of Active Synapses.
Ashrafi G, Wu Z, Farrell RJ, Ryan TA
Neuron (2017) 933: 606-615.e3. 106 004 ICC
Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling.
Pan PY, Marrs J, Ryan TA
The Journal of biological chemistry (2015) 29037: 22593-601. 106 004 ICC
Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade.
Gainey MA, Tatavarty V, Nahmani M, Lin H, Turrigiano GG
Proceedings of the National Academy of Sciences of the United States of America (2015) 11227: E3590-9. 106 004 ICC; tested species: rat
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 106 004 ICC
Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.
Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D
The Journal of biological chemistry (2014) 28913: 8973-88. 106 004 ICC; tested species: mouse
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 106 004 ICC; tested species: mouse,rat
Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.
Corvin AP, Molinos I, Little G, Donohoe G, Gill M, Morris DW, Tropea D
Neuroscience letters (2012) 5201: 51-6. 106 004 ICC
Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/- mouse model of autism spectrum disorders.
Lee K, Jung Y, Vyas Y, Skelton I, Abraham WC, Hsueh YP, Montgomery JM
Molecular autism (2022) 131: 13. 106 004 IHC; tested species: mouse
Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line.
Matsuura K, Mohamed HMA, Youssef MMM, Yoshida Y, Yamamoto T
iScience (2022) 258: 104692. 106 004 IHC; tested species: mouse
Miconazole exerts disease-modifying effects during epilepsy by suppressing neuroinflammation via NF-κB pathway and iNOS production.
Gong L, Zhu T, Chen C, Xia N, Yao Y, Ding J, Xu P, Li S, Sun Z, Dong X, Shen W, et al.
Neurobiology of disease (2022) 172: 105823. 106 004 IHC; tested species: mouse
Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis.
Dong X, Fan J, Lin D, Wang X, Kuang H, Gong L, Chen C, Jiang J, Xia N, He D, Shen W, et al.
Journal of neuroinflammation (2022) 191: 226. 106 004 IHC; tested species: rat
A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
Chepurwar S, von Loh SM, Wigger DC, Neef J, Frommolt P, Beutner D, Lang-Roth R, Kubisch C, Strenzke N, Volk AE
Human molecular genetics (2022) : . 106 004 IHC; tested species: mouse
Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.
Welch GM, Boix CA, Schmauch E, Davila-Velderrain J, Victor MB, Dileep V, Bozzelli PL, Su Q, Cheng JD, Lee A, Leary NS, et al.
Science advances (2022) 839: eabo4662. 106 004 IHC; tested species: mouse
SEQUIN: An imaging and analysis platform for quantification and characterization of synaptic structures in mouse.
Reitz SJ, Sauerbeck AD, Kummer TT
STAR protocols (2021) 21: 100268. 106 004 IHC; tested species: mouse
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Wani A, Zhu J, Ulrich JD, Eteleeb A, Sauerbeck AD, Reitz SJ, Arhzaouy K, Ikenaga C, Yuede CM, Pittman SK, Wang F, et al.
Cell reports (2021) 363: 109399. 106 004 IHC; tested species: mouse
Enhanced Multiplexing of Immunofluorescence Microscopy Using a Long-Stokes-Shift Fluorophore.
Reitz SJ, Sauerbeck AD, Kummer TT
Current protocols (2021) 18: e214. 106 004 IHC; tested species: mouse
Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea.
Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H
Cell reports (2021) 341: 108551. 106 004 IHC; tested species: mouse
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 106 004 IHC; tested species: mouse
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.
Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, et al.
Biological psychiatry (2017) 812: 124-135. 106 004 IHC
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 106 004 IHC; tested species: mouse
Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure.
Kapoor K, Bhandare AM, Nedoboy PE, Mohammed S, Farnham MM, Pilowsky PM
Neuroscience (2016) 329: 12-29. 106 004 IHC
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C
Journal of cell science (2015) 1284: 638-44. 106 004 IHC
Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis.
Shah D, Jonckers E, Praet J, Vanhoutte G, Delgado Y Palacios R, Bigot C, D'Souza DV, Verhoye M, Van der Linden A
PloS one (2013) 812: e84241. 106 004 IHC; tested species: mouse
Cat. No.: 106 004
Amount: 100 µl
Price: $395.00
Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Arias-Hervert ER, Xu N, Njus M, Murphy GG, Hou Y, Williams JA, Lentz SI, Ernst SA, Stuenkel EL
Physiological reports (2020) 89: e14428. 106 004 WB; tested species: mouse
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2.
Connor-Robson N, Booth H, Martin JG, Gao B, Li K, Doig N, Vowles J, Browne C, Klinger L, Juhasz P, Klein C, et al.
Neurobiology of disease (2019) : . 106 004 WB; tested species: rat
Degree of differentiation impacts neurobiological signature and resistance to hypoxia of SH-SY5Y cells.
Voogd EJHF, Doorn N, Levers MR, Hofmeijer J, Frega M
Journal of neural engineering (2024) 206: . 106 004 ICC; tested species: human
Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis.
Ogunmowo TH, Jing H, Raychaudhuri S, Kusick GF, Imoto Y, Li S, Itoh K, Ma Y, Jafri H, Dalva MB, Chapman ER, et al.
Nature communications (2023) 141: 2888. 106 004 ICC; tested species: mouse
Cocaine-regulated trafficking of dopamine transporters in cultured neurons revealed by a pH sensitive reporter.
Saenz J, Yao O, Khezerlou E, Aggarwal M, Zhou X, Barker DJ, DiCicco-Bloom E, Pan PY
iScience (2023) 261: 105782. 106 004 ICC; tested species: mouse
Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.
Wang S, Rhijn JV, Akkouh I, Kogo N, Maas N, Bleeck A, Ortiz IS, Lewerissa E, Wu KM, Schoenmaker C, Djurovic S, et al.
Cell reports (2022) 395: 110790. 106 004 ICC; tested species: human
Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses.
López-Hernández T, Takenaka KI, Mori Y, Kongpracha P, Nagamori S, Haucke V, Takamori S
eLife (2022) 11: . 106 004 ICC; tested species: mouse
Comparative chromatin accessibility upon BDNF stimulation delineates neuronal regulatory elements.
Ibarra IL, Ratnu VS, Gordillo L, Hwang IY, Mariani L, Weinand K, Hammarén HM, Heck J, Bulyk ML, Savitski MM, Zaugg JB, et al.
Molecular systems biology (2022) 188: e10473. 106 004 ICC; tested species: human,mouse
Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.
Liu GT, Kochlamazashvili G, Puchkov D, Müller R, Schultz C, Mackintosh AI, Vollweiter D, Haucke V, Soykan T
The EMBO journal (2022) : e109352. 106 004 ICC; tested species: rat
Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons.
Jorratt P, Ricny J, Leibold C, Ovsepian SV
Molecular neurobiology (2022) : . 106 004 ICC; tested species: mouse
Neurons derived from individual early Alzheimer's disease patients reflect their clinical vulnerability.
Ng B, Rowland HA, Wei T, Arunasalam K, Hayes EM, Koychev I, Hedegaard A, Ribe EM, Chan D, Chessell T, Ffytche D, et al.
Brain communications (2022) 46: fcac267. 106 004 ICC; tested species: human
A presynaptic phosphosignaling hub for lasting homeostatic plasticity.
Müller JA, Betzin J, Santos-Tejedor J, Mayer A, Oprişoreanu AM, Engholm-Keller K, Paulußen I, Gulakova P, McGovern TD, Gschossman LJ, Schönhense E, et al.
Cell reports (2022) 393: 110696. 106 004 ICC; tested species: mouse
Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation.
Woo MS, Ufer F, Rothammer N, Di Liberto G, Binkle L, Haferkamp U, Sonner JK, Engler JB, Hornig S, Bauer S, Wagner I, et al.
The Journal of experimental medicine (2021) 2185: . 106 004 ICC; tested species: mouse
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
Salehi MS, Neumann ID, Jurek B, Pandamooz S
International journal of molecular sciences (2021) 2216: . 106 004 ICC; tested species: rat
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Bassil R, Shields K, Granger K, Zein I, Ng S, Chih B
Nature communications (2021) 121: 5220. 106 004 ICC; tested species: human
Hyperexcitability and pharmacological responsiveness of cortical neurons derived from human iPSCs carrying epilepsy-associated sodium channel Nav1.2-L1342P genetic variant.
Que Z, Olivero-Acosta MI, Zhang J, Eaton M, Tukker AM, Chen X, Wu J, Xie J, Xiao T, Wettschurack K, Yunis L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 106 004 ICC; tested species: human
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, et al.
Autophagy (2021) : 1-20. 106 004 ICC; tested species: human
Aβ1-16 controls synaptic vesicle pools at excitatory synapses via cholinergic modulation of synapsin phosphorylation.
Anni D, Weiss EM, Guhathakurta D, Akdas YE, Klueva J, Zeitler S, Andres-Alonso M, Huth T, Fejtova A
Cellular and molecular life sciences : CMLS (2021) : . 106 004 ICC; tested species: rat
Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips.
Middelkamp HHT, Verboven AHA, De Sá Vivas AG, Schoenmaker C, Klein Gunnewiek TM, Passier R, Albers CA, 't Hoen PAC, Nadif Kasri N, van der Meer AD
Scientific reports (2021) 111: 2281. 106 004 ICC; tested species: human
m.3243A > G-Induced Mitochondrial Dysfunction Impairs Human Neuronal Development and Reduces Neuronal Network Activity and Synchronicity.
Klein Gunnewiek TM, Van Hugte EJH, Frega M, Guardia GS, Foreman K, Panneman D, Mossink B, Linda K, Keller JM, Schubert D, Cassiman D, et al.
Cell reports (2020) 313: 107538. 106 004 ICC; tested species: human
CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles.
Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, Fejtova A, et al.
Cell reports (2020) 307: 2444-2459.e7. 106 004 ICC; tested species: mouse
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J
International journal of molecular sciences (2020) 2112: . 106 004 ICC; tested species: human
Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity.
van Oostrum M, Campbell B, Seng C, Müller M, Tom Dieck S, Hammer J, Pedrioli PGA, Földy C, Tyagarajan SK, Wollscheid B
Nature communications (2020) 111: 4990. 106 004 ICC; tested species: rat
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons.
Cavallo F, Troglio F, Fagà G, Fancelli D, Shyti R, Trattaro S, Zanella M, D'Agostino G, Hughes JM, Cera MR, Pasi M, et al.
Molecular autism (2020) 111: 88. 106 004 ICC; tested species: human
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling.
Frega M, Linda K, Keller JM, Gümüş-Akay G, Mossink B, van Rhijn JR, Negwer M, Klein Gunnewiek T, Foreman K, Kompier N, Schoenmaker C, et al.
Nature communications (2019) 101: 4928. 106 004 ICC; tested species: human
Loss of Tiparp results in aberrant layering of the cerebral cortex.
Grimaldi G, Vagaska B, Ievglevskyi O, Kondratskaya E, Glover J, Matthews J
eNeuro (2019) : . 106 004 ICC; tested species: mouse
Intracellular Zn2+ transients modulate global gene expression in dissociated rat hippocampal neurons.
Sanford L, Carpenter MC, Palmer AE
Scientific reports (2019) 91: 9411. 106 004 ICC; tested species: rat
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : . 106 004 ICC; tested species: rat
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 106 004 ICC; tested species: mouse
Kinesin-3 Responds to Local Microtubule Dynamics to Target Synaptic Cargo Delivery to the Presynapse.
Guedes-Dias P, Nirschl JJ, Abreu N, Tokito MK, Janke C, Magiera MM, Holzbaur ELF
Current biology : CB (2018) : . 106 004 ICC; tested species: rat
Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics.
Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, Danglot L, Olivo-Marin JC
Nature communications (2018) 91: 698. 106 004 ICC; tested species: mouse
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
Soykan T, Kaempf N, Sakaba T, Vollweiter D, Goerdeler F, Puchkov D, Kononenko NL, Haucke V
Neuron (2017) 934: 854-866.e4. 106 004 ICC; tested species: mouse
Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice.
Hayashi S, Inoue Y, Hattori S, Kaneko M, Shioi G, Miyakawa T, Takeichi M
Scientific reports (2017) 71: 5801. 106 004 ICC; tested species: mouse
GLUT4 Mobilization Supports Energetic Demands of Active Synapses.
Ashrafi G, Wu Z, Farrell RJ, Ryan TA
Neuron (2017) 933: 606-615.e3. 106 004 ICC
Vesicular glutamate transporter 1 orchestrates recruitment of other synaptic vesicle cargo proteins during synaptic vesicle recycling.
Pan PY, Marrs J, Ryan TA
The Journal of biological chemistry (2015) 29037: 22593-601. 106 004 ICC
Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade.
Gainey MA, Tatavarty V, Nahmani M, Lin H, Turrigiano GG
Proceedings of the National Academy of Sciences of the United States of America (2015) 11227: E3590-9. 106 004 ICC; tested species: rat
Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.
Ivanova D, Dirks A, Montenegro-Venegas C, Schöne C, Altrock WD, Marini C, Frischknecht R, Schanze D, Zenker M, Gundelfinger ED, Fejtova A, et al.
The EMBO journal (2015) 348: 1056-77. 106 004 ICC
Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65.
Herrera-Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D
The Journal of biological chemistry (2014) 28913: 8973-88. 106 004 ICC; tested species: mouse
Neuronal profilin isoforms are addressed by different signalling pathways.
Murk K, Wittenmayer N, Michaelsen-Preusse K, Dresbach T, Schoenenberger CA, Korte M, Jockusch BM, Rothkegel M
PloS one (2012) 73: e34167. 106 004 ICC; tested species: mouse,rat
Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms.
Corvin AP, Molinos I, Little G, Donohoe G, Gill M, Morris DW, Tropea D
Neuroscience letters (2012) 5201: 51-6. 106 004 ICC
Dietary zinc supplementation rescues fear-based learning and synaptic function in the Tbr1+/- mouse model of autism spectrum disorders.
Lee K, Jung Y, Vyas Y, Skelton I, Abraham WC, Hsueh YP, Montgomery JM
Molecular autism (2022) 131: 13. 106 004 IHC; tested species: mouse
Synaptotagmin 2 is ectopically overexpressed in excitatory presynapses of a widely used CaMKΙΙα-Cre mouse line.
Matsuura K, Mohamed HMA, Youssef MMM, Yoshida Y, Yamamoto T
iScience (2022) 258: 104692. 106 004 IHC; tested species: mouse
Miconazole exerts disease-modifying effects during epilepsy by suppressing neuroinflammation via NF-κB pathway and iNOS production.
Gong L, Zhu T, Chen C, Xia N, Yao Y, Ding J, Xu P, Li S, Sun Z, Dong X, Shen W, et al.
Neurobiology of disease (2022) 172: 105823. 106 004 IHC; tested species: mouse
Captopril alleviates epilepsy and cognitive impairment by attenuation of C3-mediated inflammation and synaptic phagocytosis.
Dong X, Fan J, Lin D, Wang X, Kuang H, Gong L, Chen C, Jiang J, Xia N, He D, Shen W, et al.
Journal of neuroinflammation (2022) 191: 226. 106 004 IHC; tested species: rat
A mutation in ATP11A causes autosomal-dominant auditory neuropathy type 2.
Chepurwar S, von Loh SM, Wigger DC, Neef J, Frommolt P, Beutner D, Lang-Roth R, Kubisch C, Strenzke N, Volk AE
Human molecular genetics (2022) : . 106 004 IHC; tested species: mouse
Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration.
Welch GM, Boix CA, Schmauch E, Davila-Velderrain J, Victor MB, Dileep V, Bozzelli PL, Su Q, Cheng JD, Lee A, Leary NS, et al.
Science advances (2022) 839: eabo4662. 106 004 IHC; tested species: mouse
SEQUIN: An imaging and analysis platform for quantification and characterization of synaptic structures in mouse.
Reitz SJ, Sauerbeck AD, Kummer TT
STAR protocols (2021) 21: 100268. 106 004 IHC; tested species: mouse
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Wani A, Zhu J, Ulrich JD, Eteleeb A, Sauerbeck AD, Reitz SJ, Arhzaouy K, Ikenaga C, Yuede CM, Pittman SK, Wang F, et al.
Cell reports (2021) 363: 109399. 106 004 IHC; tested species: mouse
Enhanced Multiplexing of Immunofluorescence Microscopy Using a Long-Stokes-Shift Fluorophore.
Reitz SJ, Sauerbeck AD, Kummer TT
Current protocols (2021) 18: e214. 106 004 IHC; tested species: mouse
Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea.
Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H
Cell reports (2021) 341: 108551. 106 004 IHC; tested species: mouse
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 106 004 IHC; tested species: mouse
Genetically Induced Retrograde Amnesia of Associative Memories After Neuroplastin Ablation.
Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, Beesley PW, et al.
Biological psychiatry (2017) 812: 124-135. 106 004 IHC
Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
Stroobants S, Damme M, Van der Jeugd A, Vermaercke B, Andersson C, Fogh J, Saftig P, Blanz J, D'Hooge R
Neurobiology of disease (2017) 106: 255-268. 106 004 IHC; tested species: mouse
Dynamic changes in the relationship of microglia to cardiovascular neurons in response to increases and decreases in blood pressure.
Kapoor K, Bhandare AM, Nedoboy PE, Mohammed S, Farnham MM, Pilowsky PM
Neuroscience (2016) 329: 12-29. 106 004 IHC
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C
Journal of cell science (2015) 1284: 638-44. 106 004 IHC
Resting state FMRI reveals diminished functional connectivity in a mouse model of amyloidosis.
Shah D, Jonckers E, Praet J, Vanhoutte G, Delgado Y Palacios R, Bigot C, D'Souza DV, Verhoye M, Van der Linden A
PloS one (2013) 812: e84241. 106 004 IHC; tested species: mouse
Background

Synapsins are neuron-specific phosphoproteins that are exclusively associated with small synaptic vesicles, with little or no expression in other tissues including neuroendocrine cells. In mammals, three distinct synapsin genes (synapsin 1, 2, and 3) encode more than eight neuronal isoforms.
Synapsin 1 is one of the most specific markers of synapses throughout the central and peripheral nervous system. In addition to synaptic nerve terminals, the protein is also present in certain sensory nerve endings. It is expressed in two splice variants (synapsin 1a and synapsin 1b). Synapsin 1 interacts with vesicle membranes as well as with actin and spectrin.
Synapsin 2 is expressed in the nervous system and also two splice variants were described so far, while synapsin 3 shows a more restricted expression pattern and is mainly found in the hypocampus.
Synapsins are major phosphoproteins and are substrates for several protein kinases such as PKA, CaMK I and CaMK II. Synapsin 1 is widely used as reference substrate for calmodulin-dependent protein kinases.