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Secretagogin antibody - 436 004

Secretagogin is an EF-hand calcium binding protein
Guinea pig polyclonal antiserum
Cat. No.: 436 004
Amount: 100 µl
Price: $365.00
Cat. No. 436 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 2000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 up to 1 : 2000 gallery  
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 1000 up to 1 : 2000 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 276 from mouse Secretagogin (UniProt Id: Q91WD9)
Reactivity Reacts with: rat (Q6R556), mouse (Q91WD9).
Other species not tested yet.
Data sheet 436_004.pdf
Cat. No.: 436 004
Amount: 100 µl
Price: $365.00
Background

Secretagogin, also known as SCGN or SECRET, is a member of the EF-hand (E-helix-loop-F-helix-hand) superfamily of calcium-binding proteins with homology to calbindin-D28k (CALB1) and calretinin (CALB2) which are widely expressed in cells and tissues. Calcium-binding proteins of different subfamilies regulate calcium as a second messenger. Calbindin, calretinin, calmodulin, S-100, parvalbumin and troponin C are members of the low molecular weight calcium-binding protein family.

Interaction between secretagogin and vesicle trafficking proteins, including SNAP25, SNAP23, ARFGAP2, and DOC2A, suggests a possible role for SCGN in neurotransmitter and hormone release.

The secretagogin protein was isolated from pancreatic islets of Langerhans and insulinomas, and shows abundant pancreatic expression and reduced expression in thyroid, adrenal medulla, stomach, small intestine, and colon.