Cat. No.: 116 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 116 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 580 to 594 from rat Munc18-1 (UniProt Id: P61765) |
| Reactivity |
Reacts with: rat (P61765), mouse. Other species not tested yet. |
| Matching control protein/peptide | 116-0P |
| Data sheet | 116_004.pdf |
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Munc 18 is an abundant neuronal protein that tightly binds to the synaptic fusion protein syntaxin 1. It is highly homologous to the C. elegans unc-18 gene product, and weakly related to the yeast sec1, sly1, and slp1 genes.
There are three munc 18 isoforms in mammals. Munc 18-1 or 18a, also referred to as rb-sec1, n-sec1, stxbp1 and p67, is primarily expressed in neurons. Munc 18-2 or 18b, also referred to as stxbp2, and Munc 18-3 or 18c are expressed ubiquitously.