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SY SY - Synaptic Systems SY SY - Synaptic Systems

Munc 13

Mammalian homologues of the C. elegans unc-13 gene essential for exocytosis

References SySy Munc 13 antibodies

Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia.
Goldenberg NM, Silverman M
American journal of physiology. Cell physiology (2009) 2974: C1053-8.
Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways.
Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF, Davis CW
The Journal of physiology (2008) 5867: 1977-92.
Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex.
Yang CB, Kiser PJ, Zheng YT, Varoqueaux F, Mower GD
Neuroscience (2007) 1503: 603-8.
Regulation of insulin exocytosis by Munc13-1.
Sheu L, Pasyk EA, Ji J, Huang X, Gao X, Varoqueaux F, Brose N, Gaisano HY
The Journal of biological chemistry (2003) 27830: 27556-63.
Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1.
Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H, Takai Y, et al.
The Journal of cell biology (2002) 1583: 577-90.
Identification of Munc13-3 as a candidate gene for critical-period neuroplasticity in visual cortex.
Yang CB, Zheng YT, Li GY, Mower GD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2002) 2219: 8614-8.
The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice.
Augustin I, Korte S, Rickmann M, Kretzschmar HA, Südhof TC, Herms JW, Brose N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2001) 211: 10-7.
Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells.
Ashery U, Varoqueaux F, Voets T, Betz A, Thakur P, Koch H, Neher E, Brose N, Rettig J
The EMBO journal (2000) 1914: 3586-96.
Regulation of transmitter release by Unc-13 and its homologues.
Brose N, Rosenmund C, Rettig J
Current opinion in neurobiology (2000) 103: 303-11.
Differential expression of two novel Munc13 proteins in rat brain.
Augustin I, Betz A, Herrmann C, Jo T, Brose N
The Biochemical journal (1999) 337 ( Pt 3): 363-71.
Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.
Betz A, Okamoto M, Benseler F, Brose N
The Journal of biological chemistry (1997) 2724: 2520-6.
The synaptic vesicle cycle: a cascade of protein-protein interactions.
Südhof TC
Nature (1995) 3756533: 645-53.
Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins.
Brose N, Hofmann K, Hata Y, Südhof TC
The Journal of biological chemistry (1995) 27042: 25273-80.
Synaptic vesicles and exocytosis.
Jahn R, Südhof TC
Annual review of neuroscience (1994) 17: 219-46.
CYP46A1 Activation by Efavirenz Leads to Behavioral Improvement without Significant Changes in Amyloid Plaque Load in the Brain of 5XFAD Mice.
Petrov AM, Lam M, Mast N, Moon J, Li Y, Maxfield E, Pikuleva IA
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2019) : . 126 111 WB; tested species: mouse
Autaptic cultures of human induced neurons as a versatile platform for studying synaptic function and neuronal morphology.
Fenske P, Grauel MK, Brockmann MM, Dorrn AL, Trimbuch T, Rosenmund C
Scientific reports (2019) 91: 4890. 126 103 WB; KD verified; tested species: human
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
Zurawski Z, Thompson Gray AD, Brady LJ, Page B, Church E, Harris NA, Dohn MR, Yim YY, Hyde K, Mortlock DP, Jones CK, et al.
Science signaling (2019) 12569: . 126 102 WB; tested species: mouse
Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability.
Karkhanis AN, Leach AC, Yorgason JT, Uneri A, Barth S, Niere F, Alexander NJ, Weiner JL, McCool BA, Raab-Graham KF, Ferris MJ, et al.
ACS chemical neuroscience (2018) : . 126 303 WB; tested species: rat
An opposing function of paralogs in balancing developmental synapse maturation.
Favaro PD, Huang X, Hosang L, Stodieck S, Cui L, Liu YZ, Engelhardt KA, Schmitz F, Dong Y, Löwel S, Schlüter OM, et al.
PLoS biology (2018) 1612: e2006838. 126 104 WB, IHC; tested species: mouse
Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons.
Wang J, Lv X, Wu Y, Xu T, Jiao M, Yang R, Li X, Chen M, Yan Y, Chen C, Dong W, et al.
Nature communications (2018) 91: 2267. 126 103 WB; tested species: mouse
SNARE Complex-associated Proteins in the Lateral Amygdala of Macaca mullatta Following Long-term Ethanol Drinking.
Alexander NJ, Rau AR, Jimenez VA, Daunais JB, Grant KA, McCool BA
Alcoholism, clinical and experimental research (2018) : . 126 102 WB; tested species: monkey
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.
Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB, Peng HY
Cell death & disease (2018) 98: 811. 126 102 WB, IHC; KD verified; tested species: rat
Ethanol Mediated Inhibition of Synaptic Vesicle Recycling at Amygdala Glutamate Synapses Is Dependent upon Munc13-2.
Gioia DA, Alexander N, McCool BA
Frontiers in neuroscience (2017) 11: 424. 126 102 WB; tested species: mouse
Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.
Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, et al.
Neuron (2017) 953: 591-607.e10. 126 103 WB; KO verified; tested species: mouse
Inhibitory role of Munc13-1 in antigen-induced mast cell degranulation.
Higashio H, Satoh YI, Saino T
Biomedical research (Tokyo, Japan) (2017) 386: 321-329. 126 103 WB; tested species: rat
Differential Expression of Munc13-2 Produces Unique Synaptic Phenotypes in the Basolateral Amygdala of C57BL/6J and DBA/2J Mice.
Gioia DA, Alexander NJ, McCool BA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3643: 10964-10977. 126 102, 126 203 WB
How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
Acuna C, Liu X, Südhof TC
Neuron (2016) 914: 792-807. 126 103 WB
Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus.
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2015) 3516: 6544-53. 126 102 WB
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.
Ferrero JJ, Alvarez AM, Ramírez-Franco J, Godino MC, Bartolomé-Martín D, Aguado C, Torres M, Luján R, Ciruela F, Sánchez-Prieto J
The Journal of biological chemistry (2013) 28843: 31370-85. 126 103 WB; tested species: mouse
Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.
Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, et al.
Traffic (Copenhagen, Denmark) (2013) 147: 798-809. 126 103 WB
The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.
Chen Z, Cooper B, Kalla S, Varoqueaux F, Young SM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3319: 8336-51. 126 103 WB
Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP.
Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3323: 9769-80. 126 111 WB
RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
Bello OD, Zanetti MN, Mayorga LS, Michaut MA
Experimental cell research (2012) 3185: 478-88. 126 103 WB, ICC
Formation of Golgi-derived active zone precursor vesicles.
Maas C, Torres VI, Altrock WD, Leal-Ortiz S, Wagh D, Terry-Lorenzo RT, Fejtova A, Gundelfinger ED, Ziv NE, Garner CC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3232: 11095-108. 126 111 WB, ICC
Munc18-1 regulates first-phase insulin release by promoting granule docking to multiple syntaxin isoforms.
Oh E, Kalwat MA, Kim MJ, Verhage M, Thurmond DC
The Journal of biological chemistry (2012) 28731: 25821-33. 126 111 WB; tested species: mouse
Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.
Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
Journal of neurochemistry (2011) 1164: 476-85. 126 103 WB, ICC; tested species: mouse
Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis.
Ren Q, Wimmer C, Chicka MC, Ye S, Ren Y, Hughson FM, Whiteheart SW
Blood (2010) 1166: 869-77. 126 111 WB; tested species: mouse
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.
Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, et al.
Science (New York, N.Y.) (2010) 3275973: 1614-8. 126 111 WB; tested species: mouse
Active zone protein CAST is a component of conventional and ribbon synapses in mouse retina.
Deguchi-Tawarada M, Inoue E, Takao-Rikitsu E, Inoue M, Kitajima I, Ohtsuka T, Takai Y
The Journal of comparative neurology (2006) 4954: 480-96. 126 111 WB; tested species: mouse
Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 126 111 WB
Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes.
Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, et al.
Traffic (Copenhagen, Denmark) (2013) 147: 798-809. 126 111 IP; tested species: mouse
The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals.
Martín R, Durroux T, Ciruela F, Torres M, Pin JP, Sánchez-Prieto J
The Journal of biological chemistry (2010) 28523: 17907-17. 126 111 IP
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 126 103 ICC; tested species: mouse
Transient Confinement of CaV2.1 Ca2+-Channel Splice Variants Shapes Synaptic Short-Term Plasticity.
Heck J, Parutto P, Ciuraszkiewicz A, Bikbaev A, Freund R, Mitlöhner J, Alonso M, Fejtova A, Holcman D, Heine M
Neuron (2019) : . 126 103 ICC; tested species: rat
Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites.
Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser PS
Cell (2018) 1724: 706-718.e15. 126 103 ICC; tested species: mouse
Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi.
Emperador-Melero J, Huson V, van Weering J, Bollmann C, Fischer von Mollard G, Toonen RF, Verhage M
Nature communications (2018) 91: 3421. 126 111 ICC; tested species: mouse
RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes.
de Jong APH, Roggero CM, Ho MR, Wong MY, Brautigam CA, Rizo J, Kaeser PS
Neuron (2018) 982: 335-349.e7. 126 111 ICC; tested species: mouse
Visualization of Synchronous or Asynchronous Release of Single Synaptic Vesicle in Active-Zone-Like Membrane Formed on Neuroligin-Coated Glass Surface.
Funahashi J, Tanaka H, Hirano T
Frontiers in cellular neuroscience (2018) 12: 140. 126 103 ICC; tested species: rat
Riluzole attenuates the efficacy of glutamatergic transmission by interfering with the size of the readily releasable neurotransmitter pool.
Lazarevic V, Yang Y, Ivanova D, Fejtova A, Svenningsson P
Neuropharmacology (2018) : . 126 103 ICC; tested species: rat
CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife (2015) 4: . 126 103 ICC
Studying synaptic efficiency by post-hoc immunolabelling.
Ramírez-Franco J, Alonso B, Bartolomé-Martín D, Sánchez-Prieto J, Torres M
BMC neuroscience (2013) 14: 127. 126 111 ICC
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.
Bello OD, Zanetti MN, Mayorga LS, Michaut MA
Experimental cell research (2012) 3185: 478-88. 126 103 WB, ICC
Formation of Golgi-derived active zone precursor vesicles.
Maas C, Torres VI, Altrock WD, Leal-Ortiz S, Wagh D, Terry-Lorenzo RT, Fejtova A, Gundelfinger ED, Ziv NE, Garner CC
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3232: 11095-108. 126 111 WB, ICC
Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.
Bartolomé-Martín D, Ramírez-Franco J, Castro E, Sánchez-Prieto J, Torres M
Journal of cell science (2012) 125Pt 2: 422-34. 126 111 ICC; tested species: rat
Non-additive potentiation of glutamate release by phorbol esters and metabotropic mGlu7 receptor in cerebrocortical nerve terminals.
Martín R, Bartolomé-Martín D, Torres M, Sánchez-Prieto J
Journal of neurochemistry (2011) 1164: 476-85. 126 111, 126 103 ICC; tested species: mouse
A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.
Jiang X, Litkowski PE, Taylor AA, Lin Y, Snider BJ, Moulder KL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 305: 1798-809. 126 103 ICC
Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon.
Fejtova A, Davydova D, Bischof F, Lazarevic V, Altrock WD, Romorini S, Schöne C, Zuschratter W, Kreutz MR, Garner CC, Ziv NE, et al.
The Journal of cell biology (2009) 1852: 341-55. 126 103 ICC
Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis.
Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED, Garner CC
The Journal of cell biology (2008) 1815: 831-46. 126 103 ICC
An opposing function of paralogs in balancing developmental synapse maturation.
Favaro PD, Huang X, Hosang L, Stodieck S, Cui L, Liu YZ, Engelhardt KA, Schmitz F, Dong Y, Löwel S, Schlüter OM, et al.
PLoS biology (2018) 1612: e2006838. 126 104 WB, IHC; tested species: mouse
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats.
Hsieh MC, Ho YC, Lai CY, Chou D, Chen GD, Lin TB, Peng HY
Cell death & disease (2018) 98: 811. 126 102 WB, IHC; KD verified; tested species: rat
Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.
Wilhelm BG, Mandad S, Truckenbrodt S, Kröhnert K, Schäfer C, Rammner B, Koo SJ, Claßen GA, Krauss M, Haucke V, Urlaub H, et al.
Science (New York, N.Y.) (2014) 3446187: 1023-8. 126 103 IHC; tested species: mouse
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T
The EMBO journal (2014) 335: 512-27. 126 103 IHC
Active zone protein expression changes at the key stages of cerebellar cortex neurogenesis in the rat.
Juranek JK, Mukherjee K, Siddiqui TJ, Kaplan BJ, Li JY, Ahnert-Hilger G, Jahn R, Calka J
Acta histochemica (2013) 1156: 616-25. 126 102 WB, ICC, IHC
Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability.
Lanore F, Labrousse VF, Szabo Z, Normand E, Blanchet C, Mulle C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3249: 17882-93. 126 103 IHC
Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons.
Rinetti GV, Schweizer FE
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 309: 3157-66. 126 102 IHC
Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon.
Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E, Mulle C
The Journal of physiology (2010) 588Pt 12: 2133-45. 126 103 IHC; tested species: mouse
Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes.
Spiwoks-Becker I, Maus C, tom Dieck S, Fejtová A, Engel L, Wolloscheck T, Wolfrum U, Vollrath L, Spessert R
Cell and tissue research (2008) 3332: 185-95. 126 103 IHC
Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.
Vasileva M, Horstmann H, Geumann C, Gitler D, Kuner T
The European journal of neuroscience (2012) 368: 3005-20. 126 103 ELISA
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: http://www.sysy.com | E-Mail: sales@sysy.com