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Kv1.2 antibody - 402 005

Kv1.2 is a potassium channel in the nervous system
Guinea pig polyclonal purified antibody
Cat. No.: 402 005
Amount: 50 µg
Price: $460.00
Cat. No. 402 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not recommended
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 463 to 482 from rat Kv1.2 (UniProt Id: P63142)
Reactivity Reacts with: rat (P63142), mouse (P63141).
Other species not tested yet.
Remarks

WB: Kv1.2 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.

Data sheet 402_005.pdf
Cat. No.: 402 005
Amount: 50 µg
Price: $460.00
Background

A high diversity of K+ channels is formed in the nervous system by heteromeric assembly of subunits encoded by a large number of K+ channel genes. They play an important role in regulating the level of neuronal excitability.
Deletion of Kv 1.2 is lethal in mice and mutations lead to severe consequences including epileptic encephalopathy, intellectual disability and episodic ataxia in humans.