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Home > Products > 180 003

GluK2 antibody - 180 003 K.O.

GluKs are ligand-gated ion channel involved in excitatory neurotransmission
Rabbit polyclonal purified antibody
Cat. No.: 180 003
Amount: 50 µg
Price: $375.00
Cat. No. 180 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 (see remarks) gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 844 to 908 from rat GluK2 (UniProt Id: P42260)
Reactivity Reacts with: human (Q13002), rat (P42260), mouse (P39087).
Other species not tested yet.
Specificity K.O. validated PubMed: 26448475
Matching control protein/peptide 180-0P
Remarks

IHC: For best results, heat-mediated antigen retrieval (citrate buffer pH 6) is recommended.
Data sheet 180_003.pdf

References for GluK2 - 180 003

Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Scientific reports (2024) 141: 4521. 180 003 WB; tested species: mouse
A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Behavioural brain research (2021) 405: 113194. 180 003 WB, IHC-Fr; KO verified
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Hwang H, Seo J, Choi Y, Cho E, Sohn H, Jang J, Lee AR, Lee J, Kim S, Koh HY, Park M, et al.
Pharmacological research (2020) 160: 105100. 180 003 WB; tested species: mouse
Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.
Watanabe-Iida I, Konno K, Akashi K, Abe M, Natsume R, Watanabe M, Sakimura K
Journal of neurochemistry (2016) 1362: 295-305. 180 003 WB; KO verified; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 180 003 WB
Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4249: 9253-9262. 180 003 IHC-Fr; tested species: mouse
A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Behavioural brain research (2021) 405: 113194. 180 003 WB, IHC-Fr; KO verified
Cat. No.: 180 003
Amount: 50 µg
Price: $375.00
Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Scientific reports (2024) 141: 4521. 180 003 WB; tested species: mouse
A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Behavioural brain research (2021) 405: 113194. 180 003 WB, IHC-Fr; KO verified
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Hwang H, Seo J, Choi Y, Cho E, Sohn H, Jang J, Lee AR, Lee J, Kim S, Koh HY, Park M, et al.
Pharmacological research (2020) 160: 105100. 180 003 WB; tested species: mouse
Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.
Watanabe-Iida I, Konno K, Akashi K, Abe M, Natsume R, Watanabe M, Sakimura K
Journal of neurochemistry (2016) 1362: 295-305. 180 003 WB; KO verified; tested species: mouse
Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injury.
Gut IM, Beske PH, Hubbard KS, Lyman ME, Hamilton TA, McNutt PM
PloS one (2013) 85: e64423. 180 003 WB
Presenilin and APP Regulate Synaptic Kainate Receptors.
Barthet G, Moreira-de-Sá A, Zhang P, Deforges S, Castanheira J, Gorlewicz A, Mulle C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4249: 9253-9262. 180 003 IHC-Fr; tested species: mouse
A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background.
Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M
Behavioural brain research (2021) 405: 113194. 180 003 WB, IHC-Fr; KO verified
WB
ICC
IHC
IHC
IHC
IHC
Background
Ionotropic glutamate receptors (iGluRs) mediate rapid excitatory neurotransmission in the mammalian CNS. They can be subdivided into three major groups, the AMPA/GluA, NMDA/GluN, and kainate/GluK receptors (KARs).
mRNAs coding for glutamate receptors are substrates for an adenosine deaminase acting on RNA (ADAR) that increases the diversity of these proteins. KARs can be found at pre- and postsynaptic sites and are composed of five different subunits: GluK1, GluK2 and GluK3 can form homomeric receptors whereas GluK4 and GluK5 form heteromeric receptors with GluK1-3.
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