IP3-receptor type 1
Triggers release of Ca2+ from intracellular stores
Inositol 1, 4, 5 - trisphophate InsP3
is an intracellular messenger that triggers release of Ca2+
from intracellular stores. InsP3 acts by binding to specific receptors localized to endoplasmic reticulum.
There are at least three types of InsP3 receptors, of which the type 1 receptor is the most abundant. All three receptors appear to be widely expressed. Highest levels of the type 1 InsP3 receptors are found in neurons, with very high expression in the Purkinje cells of the cerebellum.