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Calreticulin mutation
CAL2 - HS-315 111-S

A neoepitope present in all Calreticulin mutations

Monoclonal mouse purified IgG
298.00 USD
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Cat. No. HS-315 111-S 100 µl purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C until use.
Applications IHC-P/FFPE: 1 : 20 up to 1 : 40 gallery  
Clone CAL2
Subtype IgG2a
Immunogen Recombinant protein corresponding to the neoepitope in human mutated calreticulin.
Reactivity Reacts with: human (P27797).
Other species not tested yet.
Specificity Specific for the neoepitope in mutated Calreticulin.
Documents protocol for IHC-P
Datasheet hs-315_111-s.pdf

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References for Calreticulin mutation - HS-315 111-S

Calreticulin mutation specific CAL2 immunohistochemistry accurately identifies rare calreticulin mutations in myeloproliferative neoplasms.
Mózes R, Gángó A, Sulák A, Vida L, Reiniger L, Timár B, Krenács T, Alizadeh H, Masszi T, Gaál-Weisinger J, Demeter J, et al.
Pathology (2018) : . HS-315 111-S IHC-P; tested species: human
A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.
Stein H, Bob R, Dürkop H, Erck C, Kämpfe D, Kvasnicka HM, Martens H, Roth A, Streubel A
Leukemia (2016) 301: 131-5. HS-315 111-S IHC-P; tested species: human
CAL2 Immunohistochemical Staining Accurately Identifies CALR Mutations in Myeloproliferative Neoplasms.
Nomani L, Bodo J, Zhao X, Durkin L, Loghavi S, Hsi ED
American journal of clinical pathology (2016) 1464: 431-8. HS-315 111-S IHC-P; tested species: human
Mutation specific immunohistochemistry is highly specific for the presence of calreticulin mutations in myeloproliferative neoplasms.
Andrici J, Farzin M, Clarkson A, Sioson L, Sheen A, Watson N, Toon CW, Koleth M, Stevenson W, Gill AJ
Pathology (2016) 484: 319-24. HS-315 111-S IHC-P; tested species: human
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Synaptic Systems GmbH | Rudolf-Wissell-Str. 28 | 37079 Göttingen | Germany
Phone: +49 (0)551/505 56-0 | Internet: | E-Mail: