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Homer1 antibody - 160 004

Homer1 , 2 and 3 are post synaptic density (PSD) proteins involved in the targeting of glutamate receptors
Guinea pig polyclonal antiserum
Cat. No.: 160 004
Amount: 100 µl
Price: $395.00
Cat. No. 160 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 200 up to 1 : 500 gallery  
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of human Homer 1 (UniProt Id: Q86YM7)
Reactivity Reacts with: human (Q86YM7), rat (Q9Z214), mouse (Q9Z2Y3).
Other species not tested yet.
Specificity Specific for Homer 1. According to Soloviev et al. (2000), aa 1 - 180 are present in isoforms a, b, c and d.
Matching control protein/peptide 160-0P
Data sheet 160_004.pdf

References for Homer1 - 160 004

EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
Ji Y, Izadi-Seitz M, Landmann A, Schwintzer L, Qualmann B, Kessels MM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 446: . 160 004 WB; tested species: rat
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 160 004 WB, ICC; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 160 004 WB; tested species: rat
Neurofilament Levels in Dendritic Spines Associate with Synaptic Status.
Gürth CM, do Rego Barros Fernandes Lima MA, Macarrón Palacios V, Cereceda Delgado AR, Hubrich J, D'Este E
Cells (2023) 126: . 160 004 ICC; tested species: rat
Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.
Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU, et al.
Frontiers in cellular neuroscience (2022) 16: 797588. 160 004 ICC; tested species: mouse
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C
International journal of biological sciences (2022) 185: 1896-1911. 160 004 ICC; tested species: rat
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, et al.
PLoS biology (2022) 203: e3001503. 160 004 ICC; tested species: rat
SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(-/-) Mice.
Lutz AK, Pérez Arévalo A, Ioannidis V, Stirmlinger N, Demestre M, Delorme R, Bourgeron T, Boeckers TM
Frontiers in molecular neuroscience (2021) 14: 773571. 160 004 ICC; tested species: human
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 160 004 ICC; tested species: rat
Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway.
Gürth CM, Dankovich TM, Rizzoli SO, D'Este E
Scientific reports (2020) 101: 20576. 160 004 ICC; tested species: rat
Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis.
Pitsch J, Kamalizade D, Braun A, Kuehn JC, Gulakova PE, Rueber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R, et al.
Annals of neurology (2020) : . 160 004 ICC; tested species: mouse
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 160 004 WB, ICC; tested species: mouse
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 160 004 ICC; tested species: mouse
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 160 004 ICC; tested species: human,rat
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 160 004 ICC; tested species: mouse
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, et al.
Cell reports (2019) 277: 2199-2211.e6. 160 004 ICC; tested species: human
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 160 004 ICC; tested species: cos cells
Sonic hedgehog expression in the postnatal brain.
Rivell A, Petralia RS, Wang YX, Clawson E, Moehl K, Mattson MP, Yao PJ
Biology open (2019) : . 160 004 ICC; tested species: rat
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 004 ICC; tested species: mouse
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients.
Jézéquel J, Johansson EM, Dupuis JP, Rogemond V, Gréa H, Kellermayer B, Hamdani N, Le Guen E, Rabu C, Lepleux M, Spatola M, et al.
Nature communications (2017) 81: 1791. 160 004 ICC; tested species: rat
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.
Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, et al.
eLife (2017) 6: . 160 004 ICC; tested species: rat
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 160 004 ICC; tested species: human
Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
Szepesi Z, Bijata M, Ruszczycki B, Kaczmarek L, Wlodarczyk J
PloS one (2013) 85: e63314. 160 004 ICC
Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy.
Cangalaya C, Wegmann S, Sun W, Diez L, Gottfried A, Richter K, Stoyanov S, Pakan J, Fischer KD, Dityatev A
Brain, behavior, and immunity (2023) : . 160 004 IHC; tested species: mouse
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury.
Van Steenbergen V, Burattini L, Trumpp M, Fourneau J, Aljović A, Chahin M, Oh H, D'Ambra M, Bareyre FM
The Journal of experimental medicine (2023) 2203: . 160 004 IHC; tested species: mouse
Correction of amygdalar dysfunction in a rat model of fragile X syndrome.
Fernandes G, Mishra PK, Nawaz MS, Donlin-Asp PG, Rahman MM, Hazra A, Kedia S, Kayenaat A, Songara D, Wyllie DJA, Schuman EM, et al.
Cell reports (2021) 372: 109805. 160 004 IHC; tested species: rat
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, et al.
Nature neuroscience (2021) 243: 355-367. 160 004 IHC; tested species: mouse
Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy.
Yeo SH, Herde MK, Herbison AE
Journal of neuroendocrinology (2021) 339: e13021. 160 004 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 160 004 IHC; tested species: rat
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 160 004 IHC; tested species: mouse
Human gestational NMDAR autoantibodies impair neonatal murine brain function.
Jurek B, Chayka M, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, et al.
Annals of neurology (2019) : . 160 004 IHC; tested species: mouse
RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.
Brockmann MM, Maglione M, Willmes CG, Stumpf A, Bouazza BA, Velasquez LM, Grauel MK, Beed P, Lehmann M, Gimber N, Schmoranzer J, et al.
eLife (2019) 8: . 160 004 IHC; tested species: mouse
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, et al.
Nature (2018) : . 160 004 IHC; tested species: mouse
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 160 004 IHC; tested species: mouse
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, et al.
Proceedings of the National Academy of Sciences of the United States of America (2016) 11341: 11615-11620. 160 004 IHC; tested species: mouse
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) (2021) 314: e12914. 160 004 IHC-P; tested species: human
Cat. No.: 160 004
Amount: 100 µl
Price: $395.00
EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation.
Ji Y, Izadi-Seitz M, Landmann A, Schwintzer L, Qualmann B, Kessels MM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 446: . 160 004 WB; tested species: rat
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 160 004 WB, ICC; tested species: mouse
Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 160 004 WB; tested species: rat
Neurofilament Levels in Dendritic Spines Associate with Synaptic Status.
Gürth CM, do Rego Barros Fernandes Lima MA, Macarrón Palacios V, Cereceda Delgado AR, Hubrich J, D'Este E
Cells (2023) 126: . 160 004 ICC; tested species: rat
Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination.
Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU, et al.
Frontiers in cellular neuroscience (2022) 16: 797588. 160 004 ICC; tested species: mouse
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C
International journal of biological sciences (2022) 185: 1896-1911. 160 004 ICC; tested species: rat
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, et al.
PLoS biology (2022) 203: e3001503. 160 004 ICC; tested species: rat
SHANK2 Mutations Result in Dysregulation of the ERK1/2 Pathway in Human Induced Pluripotent Stem Cells-Derived Neurons and Shank2(-/-) Mice.
Lutz AK, Pérez Arévalo A, Ioannidis V, Stirmlinger N, Demestre M, Delorme R, Bourgeron T, Boeckers TM
Frontiers in molecular neuroscience (2021) 14: 773571. 160 004 ICC; tested species: human
Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK.
Zieger HL, Kunde SA, Rademacher N, Schmerl B, Shoichet SA
Scientific reports (2020) 101: 5709. 160 004 ICC; tested species: rat
Synaptic activity and strength are reflected by changes in the post-synaptic secretory pathway.
Gürth CM, Dankovich TM, Rizzoli SO, D'Este E
Scientific reports (2020) 101: 20576. 160 004 ICC; tested species: rat
Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis.
Pitsch J, Kamalizade D, Braun A, Kuehn JC, Gulakova PE, Rueber T, Lubec G, Dietrich D, von Wrede R, Helmstaedter C, Surges R, et al.
Annals of neurology (2020) : . 160 004 ICC; tested species: mouse
Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like Symptoms.
Koch N, Koch D, Krueger S, Tröger J, Sabanov V, Ahmed T, McMillan LE, Wolf D, Montag D, Kessels MM, Balschun D, et al.
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 160 004 WB, ICC; tested species: mouse
SALM1 controls synapse development by promoting F-actin/PIP2-dependent Neurexin clustering.
Brouwer M, Farzana F, Koopmans F, Chen N, Brunner JW, Oldani S, Li KW, van Weering JR, Smit AB, Toonen RF, Verhage M, et al.
The EMBO journal (2019) : e101289. 160 004 ICC; tested species: mouse
Synaptic FUS Localization During Motoneuron Development and Its Accumulation in Human ALS Synapses.
Deshpande D, Higelin J, Schoen M, Vomhof T, Boeckers TM, Demestre M, Michaelis J
Frontiers in cellular neuroscience (2019) 13: 256. 160 004 ICC; tested species: human,rat
Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters.
Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC
The Journal of cell biology (2019) : . 160 004 ICC; tested species: mouse
A Single-Cell Model for Synaptic Transmission and Plasticity in Human iPSC-Derived Neurons.
Meijer M, Rehbach K, Brunner JW, Classen JA, Lammertse HCA, van Linge LA, Schut D, Krutenko T, Hebisch M, Cornelisse LN, Sullivan PF, et al.
Cell reports (2019) 277: 2199-2211.e6. 160 004 ICC; tested species: human
Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.
Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA
eLife (2019) 8: . 160 004 ICC; tested species: cos cells
Sonic hedgehog expression in the postnatal brain.
Rivell A, Petralia RS, Wang YX, Clawson E, Moehl K, Mattson MP, Yao PJ
Biology open (2019) : . 160 004 ICC; tested species: rat
Light-activated ROS production induces synaptic autophagy.
Hoffmann S, Orlando M, Andrzejak E, Bruns C, Trimbuch T, Rosenmund C, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 160 004 ICC; tested species: mouse
Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patients.
Jézéquel J, Johansson EM, Dupuis JP, Rogemond V, Gréa H, Kellermayer B, Hamdani N, Le Guen E, Rabu C, Lepleux M, Spatola M, et al.
Nature communications (2017) 81: 1791. 160 004 ICC; tested species: rat
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.
Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, et al.
eLife (2017) 6: . 160 004 ICC; tested species: rat
SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients.
Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, Krawisz A, Froehlich W, Bernstein JA, Hallmayer JF, Dolmetsch RE, et al.
Nature (2013) 5037475: 267-71. 160 004 ICC; tested species: human
Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
Szepesi Z, Bijata M, Ruszczycki B, Kaczmarek L, Wlodarczyk J
PloS one (2013) 85: e63314. 160 004 ICC
Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy.
Cangalaya C, Wegmann S, Sun W, Diez L, Gottfried A, Richter K, Stoyanov S, Pakan J, Fischer KD, Dityatev A
Brain, behavior, and immunity (2023) : . 160 004 IHC; tested species: mouse
Coordinated neurostimulation promotes circuit rewiring and unlocks recovery after spinal cord injury.
Van Steenbergen V, Burattini L, Trumpp M, Fourneau J, Aljović A, Chahin M, Oh H, D'Ambra M, Bareyre FM
The Journal of experimental medicine (2023) 2203: . 160 004 IHC; tested species: mouse
Correction of amygdalar dysfunction in a rat model of fragile X syndrome.
Fernandes G, Mishra PK, Nawaz MS, Donlin-Asp PG, Rahman MM, Hazra A, Kedia S, Kayenaat A, Songara D, Wyllie DJA, Schuman EM, et al.
Cell reports (2021) 372: 109805. 160 004 IHC; tested species: rat
Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation.
Jafari M, Schumacher AM, Snaidero N, Ullrich Gavilanes EM, Neziraj T, Kocsis-Jutka V, Engels D, Jürgens T, Wagner I, Weidinger JDF, Schmidt SS, et al.
Nature neuroscience (2021) 243: 355-367. 160 004 IHC; tested species: mouse
Morphological assessment of GABA and glutamate inputs to GnRH neurons in intact female mice using expansion microscopy.
Yeo SH, Herde MK, Herbison AE
Journal of neuroendocrinology (2021) 339: e13021. 160 004 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 160 004 IHC; tested species: rat
SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 160 004 IHC; tested species: mouse
Human gestational NMDAR autoantibodies impair neonatal murine brain function.
Jurek B, Chayka M, Kreye J, Lang K, Kraus L, Fidzinski P, Kornau HC, Dao LM, Wenke NK, Long M, Rivalan M, et al.
Annals of neurology (2019) : . 160 004 IHC; tested species: mouse
RIM-BP2 primes synaptic vesicles via recruitment of Munc13-1 at hippocampal mossy fiber synapses.
Brockmann MM, Maglione M, Willmes CG, Stumpf A, Bouazza BA, Velasquez LM, Grauel MK, Beed P, Lehmann M, Gimber N, Schmoranzer J, et al.
eLife (2019) 8: . 160 004 IHC; tested species: mouse
Required growth facilitators propel axon regeneration across complete spinal cord injury.
Anderson MA, O'Shea TM, Burda JE, Ao Y, Barlatey SL, Bernstein AM, Kim JH, James ND, Rogers A, Kato B, Wollenberg AL, et al.
Nature (2018) : . 160 004 IHC; tested species: mouse
Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 160 004 IHC; tested species: mouse
RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.
Grauel MK, Maglione M, Reddy-Alla S, Willmes CG, Brockmann MM, Trimbuch T, Rosenmund T, Pangalos M, Vardar G, Stumpf A, Walter AM, et al.
Proceedings of the National Academy of Sciences of the United States of America (2016) 11341: 11615-11620. 160 004 IHC; tested species: mouse
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) (2021) 314: e12914. 160 004 IHC-P; tested species: human
WB
ICC
IHC
IHC-P
Background

Homer is a scaffolding protein of the post synaptic density (PSD) and enriched at excitatory synapses. The protein binds metabotropic glutamate receptors, TRPC1, proteins of the Shank family and others. By aggregating these proteins into clusters, homer was suggested to organize distinct signalling domains.
Three isoforms, Homer 1, 2 and 3 have been described. Each of these isoforms is subject to alternative splicing yielding the splice variants a, b, c, d.
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