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BCAS1 antibody - 445 003

BCAS1 is a protein specific for an actively myelinating oligodendrocyte subpopulation
Rabbit polyclonal purified antibody
Cat. No.: 445 003
Amount: 50 µg
Price: $380.00
Cat. No. 445 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 2000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 1000 gallery  
IHC-P: 1 : 200 up to 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 633 from mouse BCAS1 (UniProt Id: Q80YN3)
Reactivity Reacts with: mouse (Q80YN3), rat (Q3ZB98-1).
Other species not tested yet.
Specificity Specific for BCAS1 and its isoforms
Data sheet 445_003.pdf

References for BCAS1 - 445 003

Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination.
Rosko LM, Gentile T, Smith VN, Manavi Z, Melchor GS, Hu J, Shults NV, Albanese C, Lee Y, Rodriguez O, Huang JK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 437: 1143-1153. 445 003 IHC; tested species: mouse
Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice.
Chapman TW, Olveda GE, Bame X, Pereira E, Hill RA
Nature neuroscience (2023) 264: 555-569. 445 003 IHC; tested species: mouse
PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development.
Waldhauser V, Baroti T, Fröb F, Wegner M
Cells (2023) 1212: . 445 003 IHC; tested species: mouse
Cat. No.: 445 003
Amount: 50 µg
Price: $380.00
Cerebral Creatine Deficiency Affects the Timing of Oligodendrocyte Myelination.
Rosko LM, Gentile T, Smith VN, Manavi Z, Melchor GS, Hu J, Shults NV, Albanese C, Lee Y, Rodriguez O, Huang JK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2023) 437: 1143-1153. 445 003 IHC; tested species: mouse
Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice.
Chapman TW, Olveda GE, Bame X, Pereira E, Hill RA
Nature neuroscience (2023) 264: 555-569. 445 003 IHC; tested species: mouse
PBAF Subunit Pbrm1 Selectively Influences the Transition from Progenitors to Pre-Myelinating Cells during Oligodendrocyte Development.
Waldhauser V, Baroti T, Fröb F, Wegner M
Cells (2023) 1212: . 445 003 IHC; tested species: mouse
Background

Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).