VGAT (vesicular GABA transporter, VIAAT)
GABA transporter in the membrane of synaptic vesicles
References SySy VGAT antibodies
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A & Klingauf J (2011). A readily retrievable pool of synaptic vesicles. Nature Neuroscience 14: 833-9. CypHer5E-labeled lumenal domain antibody; labeling of recycling vesiclesEllender TJ, Huerta-Ocampo I, Deisseroth K, Capogna M & Bolam JP (2011). Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. Journal of Neuroscience 31: 15340-51. guinea pig antiserum; IHC
Geis C, Weishaupt A, Hallermann S, Grünewald B, Wessig C, Wultsch T, Reif A, Byts N, Beck M, Jablonka S, Boettger MK, Üçeyler N, Fouquet W, Gerlach M, Meinck HM, Sirén AL, Sigrist SJ, Toyka KV, Heckmann M & Sommer C (2010). Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition. Brain 188: 3166-80. guinea pig antiserum; ICC
Dobie FA & Craig AM (2011). Inhibitory synapse dynamics: coordinated presynaptic and postsynaptic mobility and the major contribution of recycled vesicles to new synapse formation. Journal of Neuroscience 31: 10481-93. cytoplasmic domain rabbit antibody and guinea pig antiserum; ICC, Oyster® 550-labeled lumenal domain antibody
Micheva KD, Busse B, Weiler NC, O'Rourke N & Smith SJ (2010). Single-synapse analysis of a diverse synapse population: proteomic imaging methods and markers. Neuron 68: 639-53. Clone 117G4; IHC
Hua Y, Sinha R, Martineau M, Kahms M & Klingauf J (2010). A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nature Neuroscience 13: 1451-3. lumenal domain antibody; CypHer5E-labeled
Grumelli C, Corradini I, Matteoli M & Verderio C (2010). Intrinsic calcium dynamics control botulinum toxin A susceptibility in distinct neuronal populations. Cell Calcium 47: 419-24. lumenal domain antibody; labeling of recycling vesicles
Hughes EG, Elmariah SB & Balice-Gordon RJ (2010). Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis. Molecular and Cellular Neurosciences 43: 136-45. lumenal domain antibody; labeling of recycling vesicles
Linetti A, Fratangeli A, Taverna E, Valnegri P, Francolini M, Cappello V, Matteoli M, Passafaro M & Rosa P (2010). Cholesterol reduction impairs exocytosis of synaptic vesicles. Journal of Cell Science 123(Pt4): 595-605. guinea pig antibody; ICC
Lee H & Brecha NC (2010). Immunocytochemical evidence for SNARE protein-dependent transmitter release from guinea pig horizontal cells. European Journal of Neuroscience 31: 1388-1401. Clone 117G4; IHC
Ribic A, Zhang M, Schlumbohm C, Mätz-Rensing K, Uchanska-Ziegler B, Flügge G, Zhang W, Walter L & Fuchs E (2010). Neuronal MHC Class I Molecules are Involved in Excitatory Synaptic Transmission at the Hippocampal Mossy Fiber Synapses of Marmoset Monkeys. Cellular and Molecular Neurobiology 30: 827-39. rabbit antiserum; IHC
Pang ZP, Cao P, Xu W & Südhof TC (2010). Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. Journal of Neuroscience 30: 4132-42. rabbit antibody; ICC
Grønborg M, Pavlos NJ, Brunk I, Chua JJ, Münster-Wandowski A, Riedel D, Ahnert-Hilger G, Urlaub H & Jahn R (2010). Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. Journal of Neuroscience 30: 2-12. guinea pig antibody; ICC, IHC, EM
Fattorini G, Verderio C, Melone M, Giovedì S, Benfenati F, Matteoli M & Conti F (2009). VGLUT1 and VGAT are sorted to the same population of synaptic vesicles in subsets of cortical axon terminals. Journal of Neurochemistry 110: 1538-46. lumenal domain antibody; labeling of recycling vesicles, cytoplasmic domain rabbit antiserum; IP
Martens H, Weston MC, Boulland JL, Grønborg M, Grosche J, Kacza J, Hoffmann A, Matteoli M, Takamori S, Harkany T, Chaudhry FA, Rosenmund C, Erck C, Jahn R & Härtig W (2008). Unique Luminal Localization of VGAT-C Terminus Allows for Selective Labeling of Active Cortical GABAergic Synapses. Journal of Neuroscience 28: 13125-13131. Description of lumenal domain rabbit antibody
Ferguson SM, Brasnjo G, Hayashi M, Wölfel M, Collesi C, Giovedi S, Raimondi A, Gong LW, Ariel P, Paradise S, O'toole E, Flavell R, Cremona O, Miesenböck G, Ryan TA & De Camilli P (2007). A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis. Science 316: 570-4. WB in supplement
Baer K, Bürli T, Huh KH, Wiesner A, Erb-Vögtli S, Göckeritz-Dujmovic D, Moransard M, Nishimune A, Rees MI, Henley JM, Fritschy JM & Fuhrer C (2007). PICK1 interacts with alpha7 neuronal nicotinic acetylcholine receptors and controls their clustering. Molecular and Cellular Neurosciences 35: 339-55. cytoplasmic domain rabbit antibody and clone 117G4; ICC
Bogen IL, Boulland JL, Mariussen E, Wright MS, Fonnum F, Kao HT & Walaas SI (2006). Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters. Journal of Neurochemistry 96: 1458-66. Clone 117G4; IHC
Tafoya LC, Mameli M, Miyashita T, Guzowski JF, Valenzuela CF & Wilson MC (2006). Expression and function of SNAP-25 as a universal SNARE component in GABAergic neurons. Journal of Neuroscience 26: 7826-38. cytoplasmic domain rabbit antibody and clone 117G4; WB, ICC, IHC
Pollard KS, Salama SR, Lambert N, Lambot MA, Coppens S, Pedersen JS, Katzman S, King B, Onodera C, Siepel A, Kern AD, Dehay C, Igel H, Ares M Jr, Vanderhaeghen P & Haussler D (2006). An RNA gene expressed during cortical development evolved rapidly in humans. Nature 443: 167-72. cytoplasmic domain rabbit antibody; IHC in human
Hartman KN, Pal SK, Burrone J & Murthy VN (2006). Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons. Nature Neuroscience 9: 642-9. cytoplasmic domain rabbit antibody; ICC
Berghuis P, Dobszay MB, Wang X, Spano S, Ledda F, Sousa KM, Schulte G, Ernfors P, Mackie K, Paratcha G, Hurd YL & Harkany T (2005). Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor. Proceedings of the National Academy of Sciences USA 102: 19115-20. cytoplasmic domain rabbit antibody; ICC
Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang SM, Suemoto T, Higuchi M & Saido TC (2005). Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation. Nature Medicine 11: 434-9. Clone 117G4; IHC
Prange O, Wong TP, Gerrow K, Wang YT & El-Husseini A. (2004). A balance between excitatory and inhibitory synapses is controlled by PSD-95 and neuroligin. Proceedings of the National Academy of Sciences USA 101: 13915-20. cytoplasmic domain rabbit antibody; ICC
Geigerseder C, Doepner RF, Thalhammer A, Krieger A & Mayerhofer A (2004). Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA. Reproductive Biology and Endocrinology 2: 13. cytoplasmic domain rabbit antibody; IHC
Wojcik SM, Rhee JS, Herzog E, Sigler A, Jahn R, Takamori S, Brose N & Rosenmund C (2004). An essential role for vesicular glutamate transporter1 (VGLUT1) in postnatal development and control of quantal size. Proceedings of the National Academy of Sciences USA 101: 7158-63. cytoplasmic domain rabbit antibody; WB
Hartig W, Riedel A, Grosche J, Edwards RH, Fremeau RT Jr, Harkany T, Brauer K & Arendt T (2003). Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons. Journal of Comparative Neurologie 465: 1-10. cytoplasmic domain rabbit antibody; IHC
Geigerseder C, Doepner R, Thalhammer A, Frungieri MB, Gamel-Didelon K, Calandra RS, Kohn FM & Mayerhofer A (2003). Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. Neuroendocrinology 77: 314-23. cytoplasmic domain rabbit antibody; IHC
Takamori S, Riedel D & Jahn R (2000). Immunoisolation of GABA-specific synaptic vesicles defines a functionally distinct subset of synaptic vesicles. Journal of Neuroscience 20: 4904-11. Description of cytoplasmic domain rabbit antibody
General references VGAT
Chaudhry FA, Reimer RJ, Bellocio E, Danbolt NC, Osen KK, Edwards RH & Storm-Mathisen J (1998). The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons. Journal of Neuroscience 18: 9733-50.McIntire SL, Reimer RJ, Schuske K, Edwards RH & Jorgensen EM (1997). Identification and characterization of the vesicular GABA transporter. Nature 389: 870-6.
Sagne C, El Mestikawy S, Isambert M-F, Hamon M, Henry J-P, Giros B & Gasnier B (1997). Cloning of a functional vesicular GABA and glycine transporter by screening of genome databases. FEBS Letter 417: 177-83.
Hell JW, Maycox PR, Stadler H & Jahn R (1988). Uptake of GABA by rat brain synaptic vesicles isolated by a new procedure. EMBO Journal 7: 3023-9.
