VAP-A

A SNARE binding protein

General Information

The VAMP-associated protein A VAP-A, also referred to as VAP-33, is a ubiquitously expressed type IV membrane protein. It is composed of an N-terminal domain with an immunoglobulin-like b-sheet, a central coiled-coiled domain and a C-terminal transmembrane domain. The protein, which may be involved in vesicle trafficking, is located to the endoplasmic reticulum (ER) and ER/Golgi intermediate compartment (ERGIC). VAP-A has been shown to bind to dfifferent v- and t-SNARE proteins.
Two other isoforms, VAP-B and VAP-C, have been described in the literature so far.