VAMP 4

A v-SNARE involved in the maturation of secretory granules

General Information

VAMP 4 belongs to the family of vesicle-associated membrane proteins and has a size of 16.5 kDa. It is involved in trans-Golgi network trafficking and and the maturation of secretory granules.
VAMP 4 co-immunoprecipitates with syntaxin 6, syntaxin 16, vti1a and vti1b. The highest expression levels are observed in brain but considerable amounts are also detectable in other tissues like heart, spleen and lung. In liver an additional splice variant of approximately 25 kDa has been described.