Uncoating ATPase (hsc70)

A protein involved in the removal of the clathrin coat of vesicles

References SySy uncoating ATPase antibodies

Newmyer SL & Schmid SL (2001). Dominant-interfering Hsc70 mutants disrupt multiple stages of the clathrin-coated vesicle cycle In vivo. Journal of Cell Biology 152: 607-20. WB

Hannan LA, Newmyer SL & Schmid SL (1998). ATP- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for Hsc70. Molecular Biology of the Cell 9: 2217-29. in vivo inhibition of hsc70

Honing S, Kreimer G, Robenek H and Jockusch BM (1994). Receptor-mediated endocytosis is sensitive to antibodies against the uncoating ATPase (hsc70). Journal of Cell Science 107: 1185-96. Description of Clone 3C5

General references uncoating ATPase

Chang HC, Newmyer SL, Hull MJ, Ebersold M, Schmid SL and Mellman I (2002). Hsc70 is required for endocytosis and clathrin function in Drosophila. Journal of Cell Biology 159: 477-87.

Lafer EM (2002). Clathrin-protein interactions. Traffic 3: 513-20. Review

Paddenberg R, Wiegand C and Jockusch BM (1990). Characterization of the coated vesicle uncoating ATPase: tissue distribution, association with and activity on intact coated vesicles. European Journal of Cell Biology. 52: 60-6.