UCHL 1

A neuron specific member of the ubiquitin proteasome system.

General Information

The Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL 1) enzyme is a member of a protein family involved in the hydrolyzation of C-terminal adducts of polymeric ubiquitin to generate monomeric ubiquitin. It is abundantly expressed in neurons throughout the brain and belongs to the ubiquitin-proteasome system. This pathway is responsible for the degradation of misfolded and damaged proteins and has been postulated to play an important role in Parkinson's disease.