U1-70k

A member of the U1 snRNP

References SySy U1-70k antibodies

Ellis JD, Llères D, Denegri M, Lamond AI & Cáceres JF (2008). Spatial mapping of splicing factor complexes involved in exon and intron definition. Journal of Cell Biology 181: 921-34. IP

Kameoka S, Duque P & Konarska MM (2004). p54(nrb) associates with the 5' splice site within large transcription/splicing complexes. EMBO Journal 23: 1782-91. IP

Boehringer D, Makarov EM, Sander B, Makarova OV, Kastner B, Luhrmann R & Stark H (2004). Three-dimensional structure of a pre-catalytic human spliceosomal complex B. Nature Structural and Molecular Biology 11: 463-8.

Dodon MD, Hamaia S, Martin J & Gazzolo L (2002). Heterogeneous nuclear ribonucleoprotein A1 interferes with the binding of the human T cell leukemia virus type 1 rex regulatory protein to its response element. Journal of Biological Chemistry 277: 18744-52. WB

Kues T, Dickmanns A, Luhrmann R, Peters R & Kubitscheck U (2001). High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking. Proceedings of the National Academy of Sciences USA 98: 12021-6.

Urlaub H, Hartmuth K, Kostka S, Grelle G & Luhrmann R (2000). A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs. Journal of Biological Chemistry 275: 41458-68. IP

Liu ZR, Sargueil B & Smith CW (1998). Detection of a novel ATP-dependent cross-linked protein at the 5' splice site-U1 small nuclear RNA duplex by methylene blue-mediated photo-cross-linking. Molecular and Cellular Biology 18: 6910-20.

Wu S & Green MR (1997). Identification of a human protein that recognizes the 3' splice site during the second step of pre-mRNA splicing. EMBO Journal 16: 4421-32.

Fan XC, Myer VE & Steitz JA (1997). AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation. Genes and Development 11: 2557-68. IP

Nelissen RL, Will CL, van Venrooij WJ & Luhrmann R (1994). The association of the U1-specific 70K and C proteins with U1 snRNPs is mediated in part by common U snRNP proteins. EMBO Journal 13: 4113-25.

Kastner B, Kornstadt U, Bach M & Luhrmann R (1992). Structure of the small nuclear RNP particle U1: identification of the two structural protuberances with RNP-antigens A and 70K. Journal of Cell Biology 116: 839-49. Description of Clone H111; WB

General references U1-70k

Will CL & Luhrmann R (2001). Spliceosomal UsnRNP biogenesis, structure and function. Current Opinion in Cell Biology 13: 290-301. Review

McCullough AJ & Berget SM (2000). An intronic splicing enhancer binds U1 snRNPs to enhance splicing and select 5' splice sites. Molecular and Cellular Biology 20: 9225-35.

Will CL, Rumpler S, Klein Gunnewiek J, van Venrooij WJ & Luhrmann R (1996). In vitro reconstitution of mammalian U1 snRNPs active in splicing: the U1-C protein enhances the formation of early (E) spliceosomal complexes. Nucleic Acids Research 24: 4614-23.