Tyrosine hydroxylase

The rate limiting enzyme in catecholamine synthesis

General references tyrosine hydroxylase

Vadasz C, Smiley JF, Figarsky K, Saito M, Toth R, Gyetvai BM, Oros M, Kovacs KK, Mohan P & Wang R (2007). Mesencephalic dopamine neuron number and tyrosine hydroxylase content: Genetic control and candidate genes. Neuroscience 149: 561-72.

Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG & O'Connor DT (2007). Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation 116: 993-1006.

Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR & Dickson PW (2006). Differential distribution of group I metabotropic glutamate receptors during rat cortical development. Journal of Biological Chemistry 281: 17644-51.

Peng X, Tehranian R, Dietrich P, Stefanis L & Perez RG (2005). Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. Journal of Cell Science 118(Pt15): 3523-30.

Jeon YK, Kim SY & Jeon CJ (2001). Morphology of calretinin and tyrosine hydroxylase-immunoreactive neurons in the pig retina. Molecules and Cells 11: 250-6.

McLean JH & Shipley MT (1988). Postmitotic, postmigrational expression of tyrosine hydroxylase in olfactory bulb dopaminergic neurons. Journal of Neuroscience 8: 3658-69.

Kuczenski R (1973). Soluble, membrane-bound, and detergent-solubilized rat striatal tyrosine hydroxylase. pH-dependent cofactor binding. Journal of Biological Chemistry 248: 5074-80. no abstract available

Musacchio JM, Julou L, Kety SS & Glowinski J (1969). Increase in rat brain tyrosine hydroxylase activity produced by electroconvulsive shock. Proceedings of the National Academy of Sciences USA 63: 1117-9.