α-tubulin

A major cytoskeleton protein

References SySy α-tubulin antibodies

Oelkers JM, Vinzenz M, Nemethova M, Jacob S, Lai FP, Block J, Szczodrak M, Kerkhoff E, Backert S, Schlüter K, Stradal TE, Small JV, Koestler SA & Rottner K (2011). Microtubules as platforms for assaying actin polymerization in vivo. PloS One 6: e19931. α-tubulin, clone 3A2; ICC

Groffen AJ, Martens S, Díez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT & Verhage M (2010). Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science 327: 1614-18. α-tubulin, clone 3A2; WB in supplement

Lai FP, Szczodrak M, Oelkers JM, Ladwein M, Acconcia F, Benesch S, Auinger S, Faix J, Small JV, Polo S, Stradal TE & Rottner K (2009). Cortactin Promotes Migration and PDGF-induced Actin Reorganization by Signaling to Rho-GTPases. Molecular Biology of the Cell. 20: 3209-23. α-tubulin, clone 3A2; WB

Probst-Kepper M, Geffers R, Kröger A, Viegas N, Erck C, Hecht HJ, Lünsdorf H, Roubin R, Moharregh-Khiabani D, Wagner K, Ocklenburg F, Jeron A, Garritsen H, Arstila TP, Kekäläinen E, Balling R, Hauser H, Buer J & Weiss S (2009). GARP: a key receptor controlling FOXP3 in human regulatory T cells. Journal of Cellular and Molecular Medicine 13(9B): 3343-57. α-tubulin, clone 3A2; WB

Xue M, Stradomska A, Chen H, Brose N, Zhang W, Rosenmund C & Reim K (2008). Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system. Proceedings of the National Academy of Sciences USA 105: 7575-80. α-tubulin, clone 3A2; WB in supplement

Roll-Mecak A & Vale RD (2008). Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature 451: 363-7. glu-α-tubulin, clone 1D5

Van der Heiden K, Groenendijk BC, Hierck BP, Hogers B, Koerten HK, Mommaas AM, Gittenberger-de Groot AC & Poelmann RE (2006). Monocilia on chicken embryonic endocardium in low shear stress areas. Developmental Dynamics. 235: 19-28. glu-α-tubulin, clone 1D5; IHC

Zhang Y, Gilquin B, Khochbin S & Matthias P (2006). Two catalytic domains are required for protein deacetylation. Journal of Biological Chemistry 281: 2401-4. glu-α-tubulin, clone 1D5

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. α-tubulin, clone 3A2; WB in supplement

Rosales-Nieves AE, Johndrow JE, Keller LC, Magie CR, Pinto-Santini DM, Parkhurst SM (2006). Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino. Nature Cell Biology 8: 367-76. glu-α-tubulin, clone 1D5

Basheer R, Brown R, Ramesh V, Begum S, McCarley & RW (2005). Sleep deprivation-induced protein changes in basal forebrain: implications for synaptic plasticity. Journal of Neuroscience Research 82: 650-8. tyr-α-tubulin, clone 20C6; WB

Yoon SO, Shin S & Mercurio AM (2005). Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the α6β4 Integrin. Cancer Research 65: 2761-9. glu-α-tubulin, clone 1D5; ICC

Rudiger AH, Rudiger M, Wehland J & Weber K (1999). Monoclonal antibody ID5: epitope characterization and minimal requirements for the recognition of polyglutamylated alpha- and beta-tubulin. European Journal of Cell Biology 78: 15-20. description of the antibody glu-α-tubulin, clone 1D5

Wheatley DN, Feilen EM, Yin Z & Wheatley SP (1994). Primary cilia in cultured mammalian cells: detection with an antibody against detyrosinated alpha-tubulin (ID5) and by electron microscopy. Journal of Submicroscopic Cytolology and Patholology 26: 91-102. glu-α-tubulin, clone 1D5

Wehland J & Weber K (1987). Turnover of the carboxy-terminal tyrosine of alpha-tubulin and means of reaching elevated levels of detyrosination in living cells. Journal of Cell Science 88(Pt2): 185-203. tyr-α-tubulin, clone 20C6

General references α-

Erck C, Peris L, Andrieux A, Meissirel C, Gruber AD, Vernet M, Schweitzer A, Saoudi Y, Pointu H, Bosc C, Salin PA, Job D & Wehland J (2005). A vital role of tubulin-tyrosine-ligase for neuronal organization. Proceedings of the National Academy of Sciences USA 102: 7853-8. Δ2-tubulin

Contin MA, Sironi JJ, Barra HS & Arce CA (1999). Association of tubulin carboxypeptidase with microtubules in living cells. Biochemical Journal 339: 463-71.

Paturle-Lafanechere L, Manier M, Trigault N, Pirollet F, Mazarguil H & Job D (1994). Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies. Journal of Cell Science 107: 1529-43. Δ2-tubulin

Ersfeld K, Wehland J, Plessmann U, Dodemont H, Gerke V & Weber K (1993). Characterization of the tubulin-tyrosine ligase. Journal of Cell Biology 120: 725-32.

Rudiger M, Plessman U, Kloppel KD, Wehland J & Weber K (1992). Class II tubulin, the major brain beta tubulin isotype is polyglutamylated on glutamic acid residue 435. FEBS Letters 308: 101-5.

Caron JM, Jones AL & Kirschner MW (1985). Autoregulation of tubulin synthesis in hepatocytes and fibroblasts. Journal of Cell Biology 101: 1763-72.

Caron JM, Jones AL, Rall LB & Kirschner MW (1985). Autoregulation of tubulin synthesis in enucleated cells. Nature 317: 648-51.