Tenascin-C

A multidomain adhesion molecule

General Information

Tenascin-C, also referrred to as TN-C, Cytoactin, and J1-200/220, is a multimodular glycoprotein with neurite outgrowth-stimulating properties. It is composed of a cysteine rich amino-terminus followed by a stretch of EGF like and fibronectin type III (FNIII) repeats. Its C-terminus shows homologies to fibrinogen β and γ. In the central nervous system TN-C is transiently expressed by immature astrocytes and by subpopulations of neurons, e.g., retinal ganglion cells.