Synuclein

Protein involved in Parkinson's and Alzheimer's Disease

References SySy synuclein antibodies

Siebert H, Kahle PJ, Kramer ML, Isik T, Schlüter OM, Schulz-Schaeffer WJ & Brück W (2010). Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain. Journal of Neurochemistry 114: 1007-18. α/β synuclein; PAF blot

Cole NB, Dieuliis D, Leo P, Mitchell DC & Nussbaum RL (2008). Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification. Experimental Cell Research 314: 2076-89. WB, ICC, EM

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. WB in supplement

Colapinto M, Mila S, Giraudo S, Stefanazzi P, Molteni M, Rossetti C, Bergamasco B, Lopiano L Fasano M (2006). α-Synuclein protects SH-SY5Y cells from dopamine toxicity. Biochemical and Biophysical Research Communications 349: 1294-300. WB

Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, Aitken A, Wiltfang J, Aguzzi A, Bahn E, Baxter HC, Brose N & Otto M (2005). Unchanged survival rates of 14-3-3γ knockout mice after inoculation with pathological prion protein. Molecular and Cellular Biology 25: 1339-46. WB

Jüttner R, Moré MI, Das D, Babich A, Meier J, Henning M, Erdmann B, Mu Ller EC, Otto A, Grantyn R & Rathjen FG (2005). Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. Neuron 46: 233-45. antibody 2; WB

General references synuclein

Polymeropoulos MH (2000). Genetics of Parkinson's disease. Annals of the New York Academy of Sciences 920: 28-32. Review

Stefanova N, Seppi K, Scherfler C, Puschban Z & Wenning GK (2000). Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment. Journal of Neural Transmision Suppl. 60: 335-43.

Clayton DF & George JM (1998). The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends in Neuroscience 21: 249-54.

Goedert M, Spillantini MG & Davies SW (1998). Filamentous nerve cell inclusions in neurodegenerative diseases. Current Opinions in Neurobiology 8: 619-32.

Hardy J & Gwinn-Hardy K (1998). Genetic classification of primary neurodegenerative disease. Science 282: 1075-9.

Lavedan C (1998). The synuclein family. Genome Research 8: 871-80.

Lozano AM, Lang AE, Hutchison WD & Dostrovsky JO (1998). New developments in understanding the etiology of Parkinson's disease and in its treatment. Current Opinions in Neurobiology 8: 783-90.