Syntaxin 5

A SNARE protein involved in ER-Golgi transport

Syntaxin 5, a member of the SNARE family of proteins, is functionally related to the yeast protein Sed5p. Two syntaxin 5 isoforms (35 and 42 kDa) have been described which are generated from the same mRNA by alternative translation initiation. The longer 42 kDa variant contains an N-terminal extension carrying a putative type II ER-retrieval signal.
Syntaxin 5 forms a SNARE complex with membrin, GOSR 1, rbet1 and rsec22. A more detailed analysis revealed two subcomplexes within this complex. One contains syntaxin 5 (mainly the shorter 35 kDa variant) and GOSR 1 whereas the other is composed of syntaxin 5 (35 and 42 kDa variant), membrin, rsec22 and rbet1.
Recently syntaxin 5 has been shown to be involved in the processing and accumulation of β-APP in neuronal cells.