Snapin

General Information

Snapin, also referred to as Snapap, was initially identified as a SNAP 25 interacting protein which enhances the binding of synaptotagmin 1 to SNAREs in a phosphorylation dependent manner. Later an ubiquitous expression pattern in neuronal and non-neuronal cells and interaction with SNAP 23 was described. The protein contains heptad repeats typical for coiled coils in its C-terminal part.
The role of this protein in SNARE mediated fusion is still under discussion.