SNAP 23

Palmitoylated plasma membrane protein; ubiquitously expressed isoform of SNAP 25

General Information

SNAP 23 (synaptosome-associated protein of 23 kDa) is an ubiquitously expressed isoform and functional homologue of SNAP 25. It is resistant to cleavage by BoNT/A and E. The protein is part of the exocytotic fusion complex (v-SNARE) where it assembles with syntaxin 1 and synaptobrevin.
SNAP 23 is able to function in regulated exocytosis. Both isoforms may have their own specific binding partners and discrete, albeit mechanistically similar, functional roles within the cell.