Synaptotagmin 7

A Ca²⁺ dependent regulator of exocytosis

References SySy synaptotagmin 7 antibodies

Gustavsson N, Wang Y, Kang Y, Seah T, Chua S, Radda GK & Han W (2011). Synaptotagmin-7 as a positive regulator of glucose-induced glucagon-like peptide-1 secretion in mice. Diabetologia 54: 1824-30. WB, ICC

Mendez JA, Bourque MJ, Fasano C, Kortleven C & Trudeau LE (2011). Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels. Journal of Biological Chemistry 286: 23928-37. ICC

Abe N, Almenar-Queralt A, Lillo C, Shen Z, Lozach J, Briggs SP, Williams DS, Goldstein LS & Cavalli V (2009). Sunday Driver interacts with two distinct classes of axonal organelles. Journal of Biological Chemistry 284: 34628-39. WB, IHC

Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC & Han W (2008). Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proceedings of the National Academy of Sciences USA 105: 3992-7. ICC, IHC

Gauthier BR, Duhamel DL, Iezzi M, Theander S, Saltel F, Fukuda M, Wehrle-Haller B & Wollheim CB (2008). Synaptotagmin VII splice variants {alpha}, {beta}, and {delta} are expressed in pancreatic {beta}-cells and regulate insulin exocytosis. FASEB Journal 22: 194-206. WB, ICC

Lynch KL & Martin TF (2007). Synaptotagmins I and IX function redundantly in regulated exocytosis but not endocytosis in PC12 cells. Journal of Cell Science 120(Pt4): 617-27. WB

Osborne SL, Wallis TP, Jimenez JL, Gorman JJ & Meunier FA (2007). Identification of secretory granule phosphatidylinositol 4,5-bisphosphate-interacting proteins using an affinity pulldown strategy. Molecular and Cellular Proteomics:MPC 6: 1158-69. WB, ICC

General references synaptotagmin 7

Fukuda M, Ogata Y, Saegusa C, Kanno E & Mikoshiba K (2002). Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. Biochemical Journal 365 (Pt 1): 173-80.

Fukuda M, Katayama E & Mikoshiba K (2002). The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization. Journal of Biological Chemistry 277: 29315-20.

Sugita S, Han W, Butz S, Liu X, Fernandez-Chacon R, Lao Y & Sudhof TC (2001). Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Neuron 30: 459-73.

Fukuda M & Mikoshiba K (2001). Mechanism of the calcium-dependent multimerization of synaptotagmin VII mediated by its first and second C2 domains. Journal of Biological Chemistry 276: 27670-6.

Caler EV, Chakrabarti S, Fowler KT, Rao S & Andrew NW (2001). The exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi. Journal of Experimental Medicine 193: 1097-104.

Fukuda M & Mikoshiba K (2000). Distinct self-oligomerization activities of synaptotagmin family. Unique calcium-dependent oligomerization properties of synaptotagmin VII. Journal of Biological Chemistry 275: 28180-5.