Synaptotagmin 7

A Ca²⁺ dependent regulator of exocytosis

General Information

Synaptotagmin 7 is a proposed regulator of Ca²⁺ dependent exocytosis like neurotransmitter release. It occurs in several splicing variants which are expressed in a developmentally regulated pattern in brain. The distinct roles for the alternative splicing isoforms have not yet been determined.
Synaptotagmin 7 shows Ca²⁺ dependent oligomerization via its own C2 domains leading to the formation of large linear structures which reside at the fusion site of vesicles and plasma membrane. These oligomers may be involved in the modulation of Ca²⁺ dependent exocytosis by opening or dilating fusion pores.