Synaptotagmin 5/9

A synaptotagmin predominantly expressed in brain

General Information

Up to now at least 17 synaptotagmins have been identified. Two different synaptotagmins were independently termed Synaptotagmin 5 by two research groups (see Li et al., 1995 and Craxton & Goeder, 1995). The groups refer to the respective other protein as Synaptotagmin 9. The synaptotagmin described by Craxton & Goeder is expressed in different tissues like kidney, heart, lung and adipose tissue but shows its highest expression level in brain, where it predominantly locates to an enriched synaptic vesicle fraction. Like other synaptotagmins it contains one transmembrane and two cytosolic C2 domains.