Synaptotagmin 4
A protein targeted to the Golgi compartment and LDCVs in NGF differentiated PC12 cells
References SySy synaptotagmin 4 antibodies
Prada I, Marchaland J, Podini P, Magrassi L, D'Alessandro R, Bezzi P & Meldolesi J (2011). REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes. Journal of Biological Chemistry 193: 537-49. WBZhang G, Bai H, Zhang H, Dean C, Wu Q, Li J, Guariglia S, Meng Q & Cai D (2011). Neuropeptide exocytosis involving synaptotagmin-4 and oxytocin in hypothalamic programming of body weight and energy balance. Neuron 69: 523-35. IHC
Arthur CP, Dean C, Pagratis M, Chapman ER & Stowell MH (2010). Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons. Neuroscience 167: 135-42. WB, IP
Nowicki M, Kosacka J, Spanel-Borowski K & Borlak J (2009). Deferoxamine-induced neurite outgrowth and synapse formation in postnatal rat dorsal root ganglion (DRG) cell cultures. European Journal of Cell Biology 88: 551-62. WB
Dean C, Liu H, Dunning FM, Chang PY, Jackson MB & Chapman ER (2009). Synaptotagmin-IV modulates synaptic function and long-term potentiation by regulating BDNF release. Nature Neuroscience 12: 767-76. WB, ICC; IP in supplement
Zhang Z, Bhalla A, Dean C, Chapman ER & Jackson MB (2009). Synaptotagmin IV: a multifunctional regulator of peptidergic nerve terminals. Nature Neuroscience 12: 163-71. WB, EM
General references synaptotagmin 4
Ferguson GD, Wang H, Herschman HR & Storm DR (2004). Altered hippocampal short-term plasticity and associative memory in synaptotagmin IV (-/-) mice. Hippocampus 14: 964-74.Dai H, Shin OH, Machius M, Tomchick DR, Sudhof TC & Rizo J (2004). Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nature Structural and Molecular Biology 11: 844-9.
Ferguson GD, Herschman HR & Storm DR (2004). Reduced anxiety and depression-like behavior in synaptotagmin IV (-/-) mice. Neuropharmacology 47: 604-11.
Zhang Q, Fukuda M, Van Bockstaele E, Pascual O & Haydon PG (2004). Synaptotagmin IV regulates glial glutamate release. Proceedings of the National Acadademy of Sciences USA 101: 9441-6.
Fukuda M, Kanno E, Ogata Y, Saegusa C, Kim T, Loh YP & Yamamoto A (2003). Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells. Journal of Biological Chemistry 278: 3220-6.
Ibata K, Hashikawa T, Tsuboi T, Terakawa S, Liang F, Mizutani A, Fukuda M & Mikoshiba K (2002). Non-polarized distribution of synaptotagmin IV in neurons: evidence that synaptotagmin IV is not a synaptic vesicle protein. Neuroscience Research 43: 401-6.
Ferguson GD, Vician L & Herschman HR (2001). Synaptotagmin IV: biochemistry, genetics, behavior, and possible links to human psychiatric disease. Molecular Neurobiology 23: 173-85. Review
Fukuda M, Ibata K & Mikoshiba K (2001). A unique spacer domain of synaptotagmin IV is essential for Golgi localization. Journal of Neurochemistry 77: 730-40.
Ibata K, Fukuda M, Hamada T, Kabayama H & Mikoshiba K (2000). Synaptotagmin IV is present at the Golgi and distal parts of neurites. Journal of Neurochemistry 74: 518-26.
Thomas DM, Ferguson GD, Herschman HR & Elferink LA (1999). Functional and biochemical analysis of the C2 domains of synaptotagmin IV. Molecular Biology of the Cell 10: 2285-95.
