Synaptotagmin 2

An alternative Ca²⁺-sensor for neurotransmitter release

References SySy synaptotagmin 2 antibodies

Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M & Marcotti W (2010). Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. Nature Neuroscience 13: 45-52. cytoplasmic domain antibody; IHC

General references synaptotagmin 2

Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R & Sudhof TC (2006). Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. Journal of Neuroscience 26: 13493-504.

Pang ZP, Sun J, Rizo J, Maximov A & Sudhof TC (2006). Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO Journal 25: 2039-50.

Lee BH, Min X, Heise CJ, Xu BE, Chen S, Shu H, Luby-Phelps K, Goldsmith EJ & Cobb MH (2004). WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Molecular Cell 15: 741-51.

Lindmark IM, Karlsson A, Serrander L, Francois P, Lew D, Rasmusson B, Stendahl O & Nusse O (2002). Synaptotagmin II could confer Ca(2+) sensitivity to phagocytosis in human neutrophils. Biochimica et Biophysica Acta 1590: 159-66.

Kida Y, Sakaguchi M, Fukuda M, Mikoshiba K & Mihara K (2001). Amino acid residues before the hydrophobic region which are critical for membrane translocation of the N-terminal domain of synaptotagmin II. FEBS Letters 507: 341-5.

Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA & Sagi-Eisenberg R (1999). Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. Journal of Experimental Medicine 189: 1649-58.

Geppert M, rcher BT 3rd & Sudhof TC (1991). Synaptotagmin II. A novel differentially distributed form of synaptotagmin. Journal of Biological Chemistry 266: 13548-52.