Synaptotagmin 2
An alternative Ca2+-sensor for neurotransmitter release
General Information
Synaptotagmin 2 is an integral membrane glycoprotein of neuronal synaptic vesicles. It is very similar to synaptotagmin 1 but shows a partly complementary expression pattern in the CNS. Synaptotagmin 2 lacks a CAMK II/PKC phosphorylation site which is present in synaptotagmin 1.Recently synaptotagmin 2 has been shown to be an alternative Ca2+ sensor for fast secretion.
