Synaptotagmin 1
Ca2+-sensor on synaptic vesicles, triggers neurotransmitter release
References SySy synaptotagmin 1 antibodies
Lazarevic V, Schöne C, Heine M, Gundelfinger ED & Fejtova A (2011). Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience 31: 10189-200. lumenal domain rabbit antibody and Oyster®550-labeled mouse antibody, clone 604.2; ICCHua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A & Klingauf J (2011). A readily retrievable pool of synaptic vesicles. Nature Neuroscience 14: 833-9. Clone 604.2, CypHer5E-labeled; labeling of recycling vesicles
Groemer TW, Thiel CS, Holt M, Riedel D, Hua Y, Hüve J, Wilhelm BG & Klingauf J (2011). Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles. PLoS one 6(4): e18754. Clone 604.2, CypHer5E-labeled; labeling of recycling vesicles
Piccoli G, Condliffe SB, Bauer M, Giesert F, Boldt K, De Astis S, Meixner A, Sarioglu H, Vogt-Weisenhorn DM, Wurst W, Gloeckner CJ, Matteoli M, Sala C & Ueffing M (2011). LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool. Journal of Neuroscience 31: 2225-37. Oyster®550-labeled lumenal domain rabbit antibody; labeling of recycling vesicles
Welzel O, Henkel AW, Stroebel AM, Jung J, Tischbirek CH, Ebert K, Kornhuber J, Rizzoli SO & Groemer TW (2011). Systematic heterogeneity of fractional vesicle pool sizes and release rates of hippocampal synapses. Biophysical Journal 100: 593-601. Clone 604.2, CypHer5E-labeled; labeling of recycling vesicles
Wilhelm BG, Groemer TW & Rizzoli SO (2010). The same synaptic vesicles drive active and spontaneous release. Nature Neuroscience 13: 1454-6. Clone 604.2, ATTO 647N-labeled; lumenal domain rabbit antibody in supplement; labeling of recycling vesicles
Hua Y, Sinha R, Martineau M, Kahms M & Klingauf J (2010). A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nature Neuroscience 13: 1451-3. Clone 604.2, CypHer5E-labeled; labeling of recycling vesicles
Welzel O, Tischbirek CH, Jung J, Kohler EM, Svetlitchny A, Henkel AW, Kornhuber J & Groemer TW (2010). Synapse clusters are preferentially formed by synapses with large recycling pool sizes. PLoS One 5(10): e13514. Clone 604.2, CypHer5E-labeled; ICC
Opazo F, Punge A, Bückers J, Hoopmann P, Kastrup L, Hell SW & Rizzoli SO (2010). Limited intermixing of synaptic vesicle components upon vesicle recycling. Traffic 11: 800-12. Clone 604.2, Oyster®550- and ATTO®647N-labeled; ICC
Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS & Brose N (2007). CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131: 796-808. Clone 41.1; WB in supplement
Kishida S, Hamao K, Inoue M, Hasegawa M, Matsuura Y, Mikoshiba K, Fukuda M & Kikuchi A (2007). Dvl regulates endo- and exocytotic processes through binding to synaptotagmin. Genes to Cells 12: 49-61. Clone 604.2 fluorescence-labeled; labeling of recycling vesicles
Fernandez-Alfonso T, Kwan R & Ryan TA (2006). Synaptic vesicles interchange their membrane proteins with a large surface reservoir during recycling. Neuron 51: 179-86. Clone 604.4; labeling of recycling vesicles
Willig KI, Rizzoli SO, Westphal V, Jahn R & Hell SW (2006). STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis. Nature 440: 935-9. Clone 41.1; ICC, clone 604.1; labeling of recycling vesicles
Rizzoli SO, Bethani I, Zwilling D, Wenzel D, Siddiqui TJ, Brandhorst D & Jahn R (2006). Evidence for early endosome-like fusion of recently endocytosed synaptic vesicles. Traffic 7: 1163-76. Clone 604.2 fluorescence-labeled; labeling of recycling vesicles
Bonanomi D, Menegon A, Miccio A, Ferrari G, Corradi A, Kao HT, Benfenati F & Valtorta F (2005). Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in developing neurons. Journal of Neuroscience 25: 7299-308. Clone 41.1; ICC, clone 604.1; labeling of recycling vesicles
Evans GJO & Morgan A (2005). Phosphorylation of cysteine string protein in the brain: developmental, regional and synaptic specificity. European Journal of Neuroscience 21: 2671-80. Clone 41.1; WB, ICC
Johnson PT, Brown MN, Pulliam BC, Anderson DH & Johnson LV (2005). Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Investigative Ophtalmology and Visual Science 46: 4788-95. Rabbit antiserum (cytoplasmic domain); IHC
tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtova A, Bracko O, Gundelfinger ED & Brandstatter JH (2005). Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. Journal of Cell Biology 168: 825-36.
Lazzell DR, Belizaire R, Thakur P, Sherry DM & Janz R (2004). SV2B regulates synaptotagmin 1 by direct interaction. Journal of Biological Chemistry 279: 52124-31. Clone 41.1; IP, IHC, clone 604.1; IP, Rabbit antiserum (cytoplasmic domain); WB
Chieregatti E, Chicka MC, Chapman ER & Baldini G (2004). SNAP-23 functions in docking/fusion of granules at low Ca2+. Molecular Biology of the Cell 15: 1918-30. Clone 41.1; WB, IP
Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED & Boeckers TM (2003). Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. Journal of Histochemistry and Cytochemistry 51: 809-19. Rabbit antiserum (cytoplasmic domain); IHC
Kubota S, Kobayashi A, Mori N, Higashide T, McLaren MJ & Inana G (2002). Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119). Investigative Ophtalmology and Visual Science 43: 308-13. Rabbit antiserum (cytoplasmic domain); IHC
Wichterle H, Lieberam I, Porter JA & Jessell TM (2002). Directed differentiation of embryonic stem cells into motor neurons. Cell 110: 385-97
von Kriegstein K, Schmitz F, Link E & Sudhof T (1999). Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. European Journal of Neuroscience 11: 1335-48. Clone 41.1 and rabbit antiserum (cytoplasmic domain); WB, IHC
Chapman ER & Jahn R (1994). Calcium-dependent interaction of the cytoplasmic region of synaptotagmin with membranes. Autonomous function of a single C2-homologous domain. Journal of Biological Chemistry 269: 5735-41. Description of clone 604.1-4
Walch-Solimena C, Takei K, Marek K, Midyett K, Südhof TC, De Camilli P & Jahn R (1993). Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles. Journal of Neuroscience 13: 3895-903.
General references synaptotagmin 1
Geppert M & Sudhof TC (1998). RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. Annual Review of Neuroscience 21: 75-95. ReviewSüdhof TC (1995). The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375: 645-53. Review
Jahn R & Südhof TC (1994). Synaptic vesicles and exocytosis. Annual Review of Neuroscience 17: 219-46. Review, no abstract available
Geppert M, Goda Y, Hammer RE, Li C, Rosahl TW, Stevens CF & Südhof TC (1994). Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse. Cell 79: 717-27.
Brose N, Petrenko AG, Südhof TC & Jahn R (1992). Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science 256: 1021-5.
Perin MS, Fried VA, Mignery GA, Jahn R & Sudhof TC (1990). Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C. Nature 345: 260-3.
