Synaptopodin

An actin associated protein present in renal podocytes and telencephalic dendrites

General Information

Synaptopodin is the founding member of a new class of proline-rich actin-associated proteins. Up to now three splice variants of synaptopodin have been identified. In neurons and podocytes the protein is expressed in a differentiation dependent manner.
Synaptopodin deficient mice lack the dendritic spine apparatus and exhibit impaired activity-dependent long-term synaptic plasticity.