Synaptophysin 1

Major synaptic vesicle membrane protein; neuroendocrine tumor marker

References SySy synaptophysin 1 antibodies

Lazarevic V, Schöne C, Heine M, Gundelfinger ED & Fejtova A (2011). Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience 31: 10189-200. rabbit and guinea pig antiserum; ICC

Jacobs S, Nathwani M & Doering LC (2010). Fragile X astrocytes induce developmental delays in dendrite maturation and synaptic protein expression. BMC Neuroscience 11: 132. guinea pig antiserum; ICC

Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS & Brose N (2007). CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131: 796-808. Clone 7.2; ICC in supplement

Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA & Herms J (2006). Synapse formation and function is modulated by the amyloid precursor protein. Journal of Neuroscience 26: 7212-21. Clone 7.2; ICC with Oyster 550-labeled antibody

Wimmer VC, Horstmann H, Groh A & Kuner T (2006). Donut-like topology of synaptic vesicles with a central cluster of mitochondria wrapped into membrane protrusions: a novel structure-function module of the adult calyx of Held. Journal of Neuroscience 26: 109-16. Rabbit antiserum; IHC

Kirvell SL, Esiri M & Francis PT (2006). Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer's disease. Journal of Neurochemistry 98: 939-50. Rabbit antiserum; IHC

Lazzell DR, Belizaire R, Thakur P, Sherry DM & Janz R (2004). SV2B regulates synaptotagmin 1 by direct interaction. Journal of Biological Chemistry 279: 52124-31. Clone 7.2; IP

Reisinger C, Yelamanchili SV, Hinz B, Mitter D, Becher A, Bigalke H & Ahnert-Hilger G (2004). The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis. Journal of Neurochemistry 90: 1-8. Clone 7.2; WB, IP

Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkruger A, Verkade P & Solimena M (2004). Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nature Cell Biology 6: 207-14. Clone 7.2; WB

Morgenthaler FD, Knott GW, Floyd Sarria JC, Wang X, Staple JK, Catsicas S & Hirling H (2003). Morphological and molecular heterogeneity in release sites of single neurons. European Journal of Neuroscience 17: 1365-74. Clone 7.2 and rabbit antiserum; ICC

von Kriegstein K & Schmitz F (2003). The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. Cell Tissue Research 311: 159-73. Clone 7.2 and rabbit antiserum; IHC

Oorschot V, de Wit H, Annaert WG & Klumperman J (2002). A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. Journal of Histochemistry and Cytochemistry 50: 1067-80. Rabbit antiserum; EM

Krantz DE, Waites C, Oorschot V, Liu Y, Wilson RI, Tan PK, Klumperman J & Edwards RH (2000). A phosphorylation site regulates sorting of the vesicular acetylcholine transporter to dense core vesicles. Journal of Cell Biology 149: 379-95. Rabbit antiserum; ICC, EM

von Kriegstein K, Schmitz F, Link E & Sudhof T (1999). Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. European Journal of Neuroscience 11: 1335-48. Clone 7.2 and rabbit antiserum; WB, IHC

Becher A, Drenckhahn A, Pahner I, Margittai M, Jahn R & Ahnert-Hilger G (1999). The synaptophysin - synaptobrevin complex: a hallmark of synaptic vesicle maturation. Journal of Neuroscience 19: 1922-31. Clone 7.2; WB, IP

Jahn R, Schiebler W, Ouimet C & Greengard P (1985). A 38,000-dalton membrane protein (p38) present in synaptic vesicles. Proceedings of the National Academy of Sciences USA 82: 4137-41. Description of Clone 7.2

General references synaptophysin 1

Janz R, Sudhof TC, Hammer RE, Unni V, Siegelbaum SA & Bolshakov VY (1999). Essential roles of synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron 24: 687-700.

McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA & Südhof TC (1996). Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proceedings of the National Academy of Sciences USA 93: 4760-4.

Südhof TC (1995). The synaptic vesicle: a cascade of protein - protein interactions. Nature 375: 645-53. Review

Buckley KM, Floor E & Kelly RB (1987). Cloning and sequence analysis of cDNA encoding p38, a major synaptic vesicle protein. Journal of Cell Biology 105: 2447-56.

Leube RE, Kaiser P, Seiter A, Zimbelmann R, Franke WW, Rehm H, Knaus P, Prior P, Betz H, Reinke H et al. (1987). Synaptophysin: molecular organization and mRNA expression as determined from cloned cDNA. EMBO Journal 6: 3261-8.

Südhof TC, Lottspeich F, Greengard P, Mehl E & Jahn R (1987). A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science 238: 1142-4.