Synaptogyrin 1

Major synaptic vesicle membrane protein; tyrosine-phosphorylated

General Information

Synaptogyrin 1, also known as p29, is an integral membrane protein ubiquitously expressed in the nervous system where it is primarily localized to the membrane of small synaptic vesicles. Like synaptophysin, synaptogyrin 1 has four transmembrane domains and an extended cytoplasmic tail but it is not glycosylated.
The function of synaptogyrin 1 is unknown. It may become useful as an alternative marker for nerve terminals. Its presence in neuroendocrine cells indicates that it also may be useful as an additional marker for diagnosing neuroendocrine tumors. Synaptogyrin 1, like synaptophysin 1, is tyrosine-phosphorylated by c-src and possibly other tyrosine kinases.