Synaptobrevin 2 (VAMP 2)

Major vesicle protein involved in fusion

References SySy synaptobrevin 2 antibodies

Orenbuch A, Shalev L, Marra V, Sinai I, Lavy Y, Kahn J, Burden JJ, Staras K & Gitler D (2012). Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals. Journal of Neuroscience 32: 3969-80. rabbit antiserum; ICC

Jiang X, Litkowski PE, Taylor AA, Lin Y, Snider BJ & Moulder KL (2010). A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing. Journal of Neuroscience 30: 1798-1809. Clone 69.1; ICC

Jockusch WJ, Speidel D, Sigler A, Sørensen JB, Varoqueaux F, Rhee JS & Brose N (2007). CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Cell 131: 796-808. Clone 69.1; ICC in supplement

Stagi M, Dittrich PS, Frank N, Iliev AI, Schwille P & Neumann H (2005). Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide. Journal of Neuroscience 25: 352-62. Clone 69.1 fluorescence-labeled; ICC

Ferracci G, Miquelis R, Kozaki S, Seagar M & Leveque C (2005). Synaptic vesicle chips to assay botulinum neurotoxins. Biochemical Journal 391 (Pt 3): 659-66. Clone 69.1; WB

Johnson PT, Brown MN, Pulliam BC, Anderson DH & Johnson LV (2005). Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. Investigative Ophtalmology and Visual Science 46: 4788-95. Clone 69.1; IHC

Reisinger C, Yelamanchili SV, Hinz B, Mitter D, Becher A, Bigalke H & Ahnert-Hilger G (2004). The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis. Journal of Neurochemistry 90: 1-8. Clone 69.1; WB, IP

Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkruger A, Verkade P & Solimena M (2004). Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nature Cell Biology 6: 207-14. Clone 69.1; WB

Bezzi P, Gundersen V, Galbete JL, Seifert G, Steinhauser C, Pilati E & Volterra A (2004). Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate. Nature Neuroscience 7: 613-20.

Chieregatti E, Chicka MC, Chapman ER & Baldini G (2004). SNAP-23 functions in docking/fusion of granules at low Ca2+. Molecular Biology of the Cell 15: 1918-30.

Morgenthaler FD, Knott GW, Floyd Sarria JC, Wang X, Staple JK, Catsicas S & Hirling H (2003). Morphological and molecular heterogeneity in release sites of single neurons. European Journal of Neuroscience 17: 1365-74. Clone 69.1; ICC

von Kriegstein K & Schmitz F (2003). The expression pattern and assembly profile of synaptic membrane proteins in ribbon synapses of the developing mouse retina. Cell Tissue Research 311: 159-73.

Sherry DM, Wang MM & Frishman LJ (2003). Differential distribution of vesicle associated membrane protein isoforms in the mouse retina. Molecular Vision 9: 673-88. Clone 69.1 and rabbit antiserum; WB, IHC

Schraw TD, Lemons PP, Dean WL & Whiteheart SW (2003). A role for Sec1/Munc18 proteins in platelet exocytosis. Biochemical Journal 374: 207-17. VAMP 1, 2 and 3

Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED & Boeckers TM (2003). Brain synaptic junctional proteins at the acrosome of rat testicular germ cells. Journal of Histochemistry and Cytochemistry 51: 809-19. Clone 69.1; IHC

Mironov Jr A, Latawiec D, Wille H, Bouzamondo-Bernstein E, Legname G, Williamson RA, Burton D, DeArmond SJ, Prusiner SB & Peters PJ. (2003). Cytosolic prion protein in neurons. Journal of Neuroscience 23: 7183-93. VAMP 2 and 3

Lang T, Margittai M, Holzler H & Jahn R (2002). SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. Journal of Cell Biology 158: 751-60.

Oorschot V, de Wit H, Annaert WG & Klumperman J (2002). A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. Journal of Histochemistry and Cytochemistry 50: 1067-80. Rabbit antiserum; EM

Wichterle H, Lieberam I, Porter JA & Jessell TM (2002). Directed differentiation of embryonic stem cells into motor neurons. Cell 110: 385-97.

Chamberlain LH, Burgoyne RD & Gould GW (2001). SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis. Proceedings of the National Academy of Sciences USA 99: 5619-24. Clone 69.1; WB

Luthi A, Schwyzer L, Mateos JM, Gahwiler BH & McKinney RA (2001). NMDA receptor activation limits the number of synaptic connections during hippocampal development: Nature Neuroscience 4: 1102-7.

Ramalho-Santos J, Moreno RD, Sutovsky P, Chan AWS, Hewitson L, Wessel GM, Simerly CR & Schatten G (2000). SNAREs in mammalian sperm: possible implications for fertilization. Developmental Biology 223: 54-69. VAMP 1 and 2

Ramm G, Slot JW, James DE & Stoorvogel W (2000). Insulin recruits GLUT4 from specialized VAMP2-carrying vesicles as well as from the dynamic endosomal/Trans-Golgi network in rat adipocytes. Molecular Biology of the Cell 11: 4079-91. Clone 69.1; EM

von Kriegstein K, Schmitz F, Link E & Sudhof T (1999). Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. European Journal of Neuroscience 11: 1335-48. Clone 69.1; WB, IHC

Maienschein V, Marxen M, Volknandt W & Zimmermann H (1999). A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Glia 26: 233-44.

Edelmann L, Hanson PI, Chapman ER & Jahn R (1995). Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO Journal 14: 224-31. Description of Clone 69.1

General references synaptobrevins

Lin RC & Scheller RH (2000). Mechanisms of synaptic vesicle exocytosis. Annual Reviews of Cell and Developmental Biology 16: 19-49. Review

Jahn R & Südhof TC (1999). Membrane fusion and exocytosis. Annual Review of Biochemistry 68: 863-911. Review

Annaert WG, Becker B, Kistner U, Reth M & Jahn R (1997). Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. Journal of Cell Biology 139: 1397-410.

Edelmann L, Hanson PI, Chapman ER & Jahn R (1995). Synaptobrevin binding to synaptophysin: a potential mechanism for controlling the exocytotic fusion machine. EMBO Journal 14: 224-31.

Südhof TC (1995). The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375: 645-53. Review

Jahn R & Südhof TC (1994). Synaptic vesicles and exocytosis. Annual Review of Neuroscience 17: 219-46. Review, no abstract available

McMahon HT, Ushkaryov YA, Edelmann L, Link E, Binz T, Niemann H, Jahn R & Sudhof TC (1993). Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature 364: 346-9.

Archer BT 3rd, Ozcelik T, Jahn R, Francke U & Sudhof TC (1990). Structures and chromosomal localizations of two human genes encoding synaptobrevins 1 and 2. Journal of Biological Chemistry 265: 17267-73.

Sudhof TC, Baumert M, Perin MS & Jahn R (1989). A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron 2: 1475-81.

Elferink LA, Trimble WS & Scheller RH (1989). Two vesicle-associated membrane protein genes are differentially expressed in the rat central nervous system. Journal of Biological Chemistry 264: 11061-4.

Baumert M, Maycox PR, Navone F, De Camilli P & Jahn R (1989). Synaptobrevin: an integral membrane protein of 18,000 daltons present in small synaptic vesicles of rat brain. EMBO Journal 8: 379-84.

Trimble WS, Cowan DM & Scheller RH (1988). VAMP-1: a synaptic vesicle-associated integral membrane protein. Proceedings of the National Academy of Sciences USA 85: 4538-42.