RIM 2

A protein of the cytomatrix assembled at the active zone

References SySy RIM 2 antibodies

Lazarevic V, Schöne C, Heine M, Gundelfinger ED & Fejtova A (2011). Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience 31: 10189-200. Zn-finger domain antibody; WB, ICC

Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A & Klingauf J (2011). A readily retrievable pool of synaptic vesicles. Nature Neuroscience 14: 833-9. Zn-finger domain antibody; ICC

Uthaiah RC & Hudspeth AJ (2010). Molecular anatomy of the hair cell's ribbon synapse. Journal of Neuroscience 30: 12387-99. PDZ domain; WB

Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M & Mori Y (2010). RIM γ isoforms lacking the Rab3-binding domain induce long-lasting currents but block neurotransmitter vesicle-anchoring in voltage-dependent P/Q-type Ca2+ channels. Journal of Biological Chemistry 285: 21750-67. Zn-finger domain antibody; WB, IP

Gebhart M, Juhasz-Vedres G, Zuccotti A, Brandt N, Engel J, Trockenbacher A, Kaur G, Obermair GJ, Knipper M, Koschak A & Striessnig J (2010). Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. Molecular and Cellular Neurosciences 44: 246-59. rabbit antibody 1; IHC

Regus-Leidig H, Tom Dieck S, Specht D, Meyer L & Brandstätter JH (2009). Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: the involvement of precursor spheres. Journal of Comparative Neurology 512: 812-24. rabbit antibody 1; IHC

Kwan EP, Xie L, Sheu L, Ohtsuka T & Gaisano HY (2007). Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells. Diabetes 56: 2579-88. rabbit antibody 1; WB

Khanna R, Zougman A & Stanley EF (2007). A proteomic screen for presynaptic terminal N-type calcium channel (CaV2.2) binding partners. Journal of Biochemistry and Molecular Biology 40: 302-14.

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. WB in supplement

Juranek J, Mukherjee K, Rickmann M, Martens H, Calka J, Südhof TC & Jahn R (2006). Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification. European Journal of Neuroscience 24: 3043-52. WB, IHC

Inoue E, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Kitajima I, Ohtsuka T & Takai Y (2006). ELKS, a protein structurally related to the active zone protein CAST, is involved in Ca2+-dependent exocytosis from PC12 cells. Genes to Cells 11: 659-72. WB, ICC

Ohara-Imaizumi M, Ohtsuka T, Matsushima S, Akimoto Y, Nishiwaki C, Nakamichi Y, Kikuta T, Nagai S, Kawakami H, Watanabe T & Nagamatsu S (2005). ELKS, a protein structurally related to the active zone-associated protein CAST, is expressed in pancreatic beta cells and functions in insulin exocytosis: interaction of ELKS with exocytotic machinery analyzed by total internal reflection fluorescence microscopy. Molecular Biology of the Cell 16: 3289-300. WB

tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtova A, Bracko O, Gundelfinger ED & Brandstatter JH (2005). Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. Journal of Cell Biology 168: 825-36. WB, IHC

General references RIM 2

Wang Y & Sudhof TC (2003). Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins (small star, filled). Genomics 81: 126-37.

Wang Y, Sugita S & Sudhof TC (2000). The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Journal of Biological Chemistry 275: 20033-44.