RIM 1
A putative Rab 3 effector protein of the active zone
References SySy RIM 1 antibodies
Lazarevic V, Schöne C, Heine M, Gundelfinger ED & Fejtova A (2011). Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience 31: 10189-200. Zn-finger domain antibody; WB, ICCHua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A & Klingauf J (2011). A readily retrievable pool of synaptic vesicles. Nature Neuroscience 14: 833-9. Zn-finger domain antibody; ICC
Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M & Mori Y (2010). RIM γ isoforms lacking the Rab3-binding domain induce long-lasting currents but block neurotransmitter vesicle-anchoring in voltage-dependent P/Q-type Ca2+ channels. Journal of Biological Chemistry 285: 21750-67. Zn-finger domain antibody; WB, IP
Regus-Leidig H, Tom Dieck S, Specht D, Meyer L & Brandstätter JH (2009). Early steps in the assembly of photoreceptor ribbon synapses in the mouse retina: the involvement of precursor spheres. Journal of Comparative Neurology 512: 812-24. rabbit antibody 1; IHC
Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED & Garner CC (2008). Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. Journal of Cell Biology 181: 831-46. rabbit antibody 1; ICC
Andrews-Zwilling YS, Kawabe H, Reim K, Varoqueaux F & Brose N (2006). Binding to Rab3A-interacting molecule RIM regulates the presynaptic recruitment of Munc13-1 and ubMunc13-2. Journal of Biological Chemistry 281: 19720-31. ICC
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. WB in supplement
Juranek J, Mukherjee K, Rickmann M, Martens H, Calka J, Sudhof TC & Jahn R (2006). Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification. European Journal of Neuroscience 24: 3043-52. WB, IHC
tom Dieck S, Altrock WD, Kessels MM, Qualmann B, Regus H, Brauner D, Fejtova A, Bracko O, Gundelfinger ED & Brandstatter JH (2005). Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of the ribbon complex. Journal of Cell Biology 168: 825-36. WB, IHC
Jüttner R, Moré MI, Das D, Babich A, Meier J, Henning M, Erdmann B, Mu Ller EC, Otto A, Grantyn R & Rathjen FG (2005). Impaired synapse function during postnatal development in the absence of CALEB, an EGF-like protein processed by neuronal activity. Neuron 46: 233-45. PDZ-domain antibody; WB
General references RIM 1
Wang Y & Sudhof TC (2003). Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins (small star, filled). Genomics 81: 126-37.Castillo PE, Schoch S, Schmitz F, Sudhof TC & Malenka RC (2002). RIM1alpha is required for presynaptic long-term potentiation. Nature 415: 327-30.
Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC & Sudhof TC (2002). RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature 415: 321-6.
Wang Y, Sugita S & Sudhof TC (2000). The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. Journal of Biological Chemistry 275: 20033-44.
Wang Y, Okamoto M, Schmitz F, Hofmann K & Sudhof TC (1997). Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature 388: 593-8.
