Rabphilin 3

Rab3-dependent synaptic vesicle Ca ²⁺-sensor

References SySy rabphilin 3 antibodies

Morciano M, Beckhaus T, Karas M, Zimmermann H & Volknandt W (2009). The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels. Journal of Neurochemistry 108: 662-75. WB

Yang S, Farias M, Kapfhamer D, Tobias J, Grant G, Abel T & Bucan M (2007). Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes, Brain and Behavior 6: 77-96. WB

Valentijn JA, van Weeren L, Ultee A & Koster AJ (2007). Novel localization of Rab3D in rat intestinal goblet cells and Brunner's gland acinar cells suggests a role in early Golgi trafficking. American Journal of Physiology. Gastrointestinal and Liver Physiology 293: G165-77. IHC

Riedel D, Antonin W, Fernandez-Chacon R, Alvarez de Toledo G, Jo T, Geppert M, Valentijn JA , Valentijn K, Jamieson JD, Sudhof TC & Jahn R (2002). Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Molecular and Cellular Biology 22: 6487-97.

Chamberlain LH, Burgoyne RD & Gould GW (2001). SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proceedings of the National Academy of Sciences USA 98: 5619-24. WB

Wang X, Kibschull M, Laue MM,Lichte B, Petrasch-Parwez E & Kilimann MW (1999). Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds Profilin. Journal of Cell Biology 147: 151-62.

General references rabphilin 3

Shirataki H, Sasaki T & Takai Y (2001). Rabphilin-3: a target molecule for Rab3 small G proteins. Methods in Enzymology 329: 75-82. No abstract available

Schluter OM, Schnell E, Verhage M, Tzonopoulos T, Nicoll RA, Janz R, Malenka RC, Geppert M & Sudhof TC (1999). Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. Journal of Neuroscience 19: 5834-46.

Fernandez-Chacon R & Sudhof TC (1999). Genetics of synaptic vesicle function: toward the complete functional anatomy of an organelle. Annual Reviews of Physiology 61: 753-76. Review

Stahl B, Chou JH, Li C, Sudhof TC & Jahn R (1996). Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. EMBO Journal 15: 1799-809.

Li C, Takei K, Geppert M, Daniell L, Stenius K, Chapman ER, Jahn R, De Camilli P & Sudhof TC (1994). Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C. Neuron 13: 885-98.

Shirataki H, Kaibuchi K, Sakoda T, Kishida S, Yamaguchi T, Wada K, Miyazaki M & Takai Y (1993). Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin. Molecular & Cellular Biology 13: 2061-8.