Rab-GDI

Cytoplasmatic protein that binds to GDP-rabs

General Information

Rab-GDI forms complexes exclusively with the GDP-form of rab proteins. Complex formation shields the geranylgeranyl moieties of rabs and leads to their dissociation from the membrane.
There are several isoforms of rab-GDI which nondiscriminately interact with all rab proteins including rab 3 and rab 5 but not with other small GTPases such as members of the rho or ras families. GDI-α is predominantly expressed in brain whereas other isoforms are more generally distributed.