Rab 3
Major rab protein in brain; highly enriched on synaptic vesicles
References SySy rab 3 antibodies
de Wit H, Walter AM, Milosevic I, Gulyás-Kovács A, Riedel D, Sørensen JB & Verhage M (2009). Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138: 935-46. Rab 3 rabbit antibody; WBCai H, Reim K, Varoqueaux F, Tapechum S, Hill K, Sørensen JB, Brose N & Chow RH (2009). Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming. Proceedings of the National Academy of Sciences USA 105: 19538-43. Rab 3c antibody; WB
Yang S, Farias M, Kapfhamer D, Tobias J, Grant G, Abel T & Bucan M (2007). Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse. Genes, Brain & Behavior 6: 77-96. Clone 42.2; WB, IP
Barile M, Pisitkun T, Yu MJ, Chou CL, Verbalis MJ, Shen RF & Knepper MA (2005). Large scale protein identification in intracellular aquaporin-2 vesicles from renal inner medullary collecting duct. Molecular and Cellular Proteomics 4: 1095-106. Clone 42.1; WB
Rastaldi MP, Armelloni S, Berra S, Li M, Pesaresi M, Poczewski H, Langer B, Kerjaschki D, Henger A, Blattner SM, Kretzler M, Wanke R & D'Amico G (2003). Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector Rabphilin-3a. American Journal of Pathology 163: 889-899. Rab 3a rabbit antibody; IHC
Morante-Redolat JM, Gorostidi-Pagola A, Piquer-Sirerol S, Saenz A, Poza JJ, Galan J, Gesk S, Sarafidou T, Mautner VF, Binelli S, Staub E, Hinzmann B, French L, Prud'homme J-F, Passarelli D, Scannapieco P, Tassinari CA, Avanzini G, Marti-Masso JF, Kluwe L, Deloukas P, Moschonas NK, Michelucci R, Siebert R, Nobile C, Perez-Tur J & Lopez de Munain A (2002). Mutations in the LGI1/Epitempin gene on 10q24 cause autosomal dominant lateral temporal epilepsy. Human Molecular Genetics 11: 1119-28. Clone 42.1; ICC
Riedel D, Antonin W, Fernandez-Chacon R, Alvarez de Toledo G, Jo T, Geppert M, Valentijn JA , Valentijn K, Jamieson JD, Sudhof TC & Jahn R (2002). Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Molecular and Cellular Biology 22: 6487-97. Clone 42.2; WB
Lang T, Margittai M, Holzler H & Jahn R (2002). SNAREs in native plasma membranes are active and readily form core complexes with endogenous and exogenous SNAREs. Journal of Cell Biology 158: 751-60.
Schluter OM, Khvotchev M, Jahn R & Sudhof TC (2002). Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. Journal of Biological Chemistry 277: 40919-29. Clone 42.1, 42.2, rab 3a rabbit antibody; WB, IHC
Oorschot V, de Wit H, Annaert WG & Klumperman J (2002). A novel flat-embedding method to prepare ultrathin cryosections from cultured cells in their in situ orientation. Journal of Histochemistry & Cytochemistry 50: 1067-80. Clone 42.2; EM
Chamberlain LH, Burgoyne RD & Gould GW (2001). SNARE proteins are highly enriched in lipid rafts in PC12 cells: Implications for the spatial control of exocytosis. Proceedings of the National Academy of Sciences USA 99: 5619-24. WB
Schlüter OM, Schnell E, Verhage M, Tzonopoulos T, Nicoll RA, Janz R, Malenka RC, Geppert M & Südhof TC. (1999). Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. Journal of Neuroscience 19: 5834-46. Clone 42.2; WB, IHC
Maienschein V, Marxen M, Volknandt W & Zimmermann H (1999). A plethora of presynaptic proteins associated with ATP-storing organelles in cultured astrocytes. Glia 26: 233-44.
von Kriegstein K, Schmitz F, Link E & Sudhof T (1999). Distribution of synaptic vesicle proteins in the mammalian retina identifies obligatory and facultative components of ribbon synapses. European Journal of Neuroscience 11: 1335-48. Clone 42.1, 42.2, rab 3a rabbit antibody; WB, IHC
Wang X, Kibschull M, Laue MM, Lichte B, Petrasch-Parwez E & Kilimann MW (1999). Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. Journal of Cell Biology 147:151-62.
Li C, Takei K, Geppert M, Daniell L, Stenius K, Chapman ER, Jahn R, De Camilli P & Südhof TC (1994). Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C. Neuron 13: 885-98. Clone 42.1, 42.2; WB, IHC
Baumert M, Fischer von Mollard G, Jahn R & Südhof TC (1993). Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes. Biochemical Journal 293: 157-63. Further description of Clones 42.1 and 42.2
Matteoli M, Takei K, Cameron R, Hurlbut P, Johnston PA, Jahn R, Südhof TC & De Camilli P (1991). Association of Rab3A with synaptic vesicles at late stages of the secretory pathway. Journal of Cell Biology 115: 625-33. Description of Clones 42.1 and 42.2; WB, ICC, IHC EM
General references rab 3
Chen X, Ernst SA & Williams JA (2003). Dominant negative Rab3D mutants reduce GTP-bound endogenous Rab3D in pancreatic acini. Journal of Biological Chemistry 278: 50053-60.Millar AL, Pavios NJ, Xu J & Zheng MH (2002). Rab3D: a regulator of exocytosis in non-neuronal cells. Histology and Histopathology 17: 929-36. Review
Pavlos NJ, Xu J, Papadimitriou JM & Zheng MH (2001). Molecular cloning of the mouse homologue of Rab3c. Journal of Molecular Endocrinology 27: 117-22.
Geppert M & Sudhof TC (1998). RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. Annual Review of Neuroscience 21: 75-95. Review
Lin CG, Lin YC, Liu HW & Kao LS (1997). Characterization of Rab3A, Rab3B and Rab3C: different biochemical properties and intracellular localization in bovine chromaffin cells. Biochemical Journal 324(Pt1): 85-90.
Geppert M, Goda Y, Stevens CF & Südhof TC (1997). The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387: 810-4.
Südhof TC (1995). The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375: 645-53. Review
Fischer von Mollard G, Stahl B, Khokhlatchev A, Sudhof TC & Jahn R (1994). Rab3C is a synaptic vesicle protein that dissociates from synaptic vesicles after stimulation of exocytosis. Journal of Biological Chemistry 269: 10971-4.
Fischer von Mollard G, Stahl B, Walch-Solimena C, Takei K, Daniels L, Khoklatchev A, De Camilli P, Südhof TC & Jahn R (1994). Localization of Rab5 to synaptic vesicles identifies endosomal intermediate in synaptic vesicle recycling pathway. European Journal of Cell Biology 65: 319-26.
Jahn R & Südhof TC (1994). Synaptic vesicles and exocytosis. Annual Review of Neuroscience 17: 219-46. Review, no abstract available
