Rab 27

A member of the Rab family responsible for melanosomal transport and hormone secretion

References SySy rab 27 antibodies

Pavlos NJ, Grønborg M, Riedel D, Chua JJ, Boyken J, Kloepper TH, Urlaub H, Rizzoli SO & Jahn R (2010). Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Journal of Neuroscience 30: 13441-53. rab 27A-; WB, rab 27B-antibody; WB, ICC in supplement

de Wit H, Walter AM, Milosevic I, Gulyás-Kovács A, Riedel D, Sørensen JB & Verhage M (2009). Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138: 935-46. Rab 27; WB

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A & Regazzi R (2008). Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 57: 2728-36. Rab 27A; WB

General references rab 27

Mahoney TR, Liu Q, Itoh T, Luo S, Hadwiger G, Vincent R, Wang ZW, Fukuda M & Nonet ML (2006). Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Molecular Biology of the Cell 17: 2617-25.

Jordens I, Westbroek W, Marsman M, Rocha N, Mommaas M, Huizing M, Lambert J, Naeyaert JM & Neefjes J (2006). Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Pigment Cell Research 19: 412-23.

Tsuboi T & Fukuda M (2006). Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. Journal of Cell Science 119(Pt 11): 2196-203.

Aslan D, Sari S, Derinoz O & Dalgic B (2006). Griscelli syndrome: description of a case with Rab27A mutation. Pediatric Hematology and Oncology 23: 255-61. Review

Izumi T, Gomi H & Torii S (2005). Functional analysis of Rab27a effector granuphilin in insulin exocytosis. Methods in Enzymology 403: 216-29.

Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H & Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. Journal of Clinical Investigation 115: 388-96.

Aizawa T & Komatsu M (2005). Rab27a: a new face in beta cell metabolism-secretion coupling. Journal of Clinical Investigation 115: 227-30. Review

Chen X, Li C, Izumi T, Ernst SA, Andrews PC & Williams JA (2004). Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochemical and Biophysical Research Communications 323: 1157-62.

Westbroek W, Lambert J, De Schepper S, Kleta R, Van Den Bossche K, Seabra MC, Huizing M, Mommaas M & Naeyaert JM (2004). Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Research 17: 498-505.

Imai A, Yoshie S, Nashida T, Shimomura H & Fukuda M (2004). The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Journal of Cell Science 117 (Pt 10): 1945-53.

Kuroda TS & Fukuda M (2004). Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Nature Cell Biology 6: 1195-203.

Futter CE, Ramalho JS, Jaissle GB, Seeliger MW & Seabra MC (2004). The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Molecular Biology of the Cell 15: 2264-75.

Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C & Seabra MC (2004). A general role for Rab27a in secretory cells. Molecular Biology of the Cell 15: 332-44.

Tiwari S, Italiano JE Jr, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC & Shivdasani RA (2003). A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood 102: 3970-9.

Larijani B, Hume AN, Tarafder AK & Seabra MC (2003). Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. Journal of Biological Chemistry 278: 46798-804.

Bahadoran P, Busca R, Chiaverini C, Westbroek W, Lambert J, Bille K, Valony G, Fukuda M, Naeyaert JM, Ortonne JP & Ballotti R (2003). Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. Journal of Biological Chemistry 278: 11386-92.

Menasche G, Feldmann J, Houdusse A, Desaymard C, Fischer A, Goud B & de Saint Basile G (2003). Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. Blood 101: 2736-42.

Zhao S, Torii S, Yokota-Hashimoto H, Takeuchi T & Izumi T (2002). Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology 143: 1817-24.

Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T & Izumi T (2002). Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Letters 517: 233-8.

Wu X, Wang F, Rao K, Sellers JR & Hammer JA 3rd. (2002). Rab27a is an essential component of melanosome receptor for myosin Va. Molecular Biology of the Cell 13: 1735-49.

Chen D, Guo J, Miki T, Tachibana M & Gahl WA (1997). Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochemical and Molecular Medicine 60: 27-37.