Rab 27

A member of the Rab family responsible for melanosomal transport and hormone secretion

References SySy rab 27 antibodies

de Wit H, Walter AM, Milosevic I, Gulyás-Kovács A, Riedel D, Sørensen JB & Verhage M (2009). Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes. Cell 138: 935-46. Rab 27; WB

Lovis P, Roggli E, Laybutt DR, Gattesco S, Yang JY, Widmann C, Abderrahmani A & Regazzi R (2008). Alterations in microRNA expression contribute to fatty acid-induced pancreatic beta-cell dysfunction. Diabetes 57: 2728-36. Rab 27A; WB

General references rab 27

Mahoney TR, Liu Q, Itoh T, Luo S, Hadwiger G, Vincent R, Wang ZW, Fukuda M & Nonet ML (2006). Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans. Molecular Biology of the Cell 17: 2617-25.

Jordens I, Westbroek W, Marsman M, Rocha N, Mommaas M, Huizing M, Lambert J, Naeyaert JM & Neefjes J (2006). Rab7 and Rab27a control two motor protein activities involved in melanosomal transport. Pigment Cell Research 19: 412-23.

Tsuboi T & Fukuda M (2006). Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells. Journal of Cell Science 119(Pt 11): 2196-203.

Aslan D, Sari S, Derinoz O & Dalgic B (2006). Griscelli syndrome: description of a case with Rab27A mutation. Pediatric Hematology and Oncology 23: 255-61. Review

Izumi T, Gomi H & Torii S (2005). Functional analysis of Rab27a effector granuphilin in insulin exocytosis. Methods in Enzymology 403: 216-29.

Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H & Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. Journal of Clinical Investigation 115: 388-96.

Aizawa T & Komatsu M (2005). Rab27a: a new face in beta cell metabolism-secretion coupling. Journal of Clinical Investigation 115: 227-30. Review

Chen X, Li C, Izumi T, Ernst SA, Andrews PC & Williams JA (2004). Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochemical and Biophysical Research Communications 323: 1157-62.

Westbroek W, Lambert J, De Schepper S, Kleta R, Van Den Bossche K, Seabra MC, Huizing M, Mommaas M & Naeyaert JM (2004). Rab27b is up-regulated in human Griscelli syndrome type II melanocytes and linked to the actin cytoskeleton via exon F-Myosin Va transcripts. Pigment Cell Research 17: 498-505.

Imai A, Yoshie S, Nashida T, Shimomura H & Fukuda M (2004). The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. Journal of Cell Science 117 (Pt 10): 1945-53.

Kuroda TS & Fukuda M (2004). Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes. Nature Cell Biology 6: 1195-203.

Futter CE, Ramalho JS, Jaissle GB, Seeliger MW & Seabra MC (2004). The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells. Molecular Biology of the Cell 15: 2264-75.

Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C & Seabra MC (2004). A general role for Rab27a in secretory cells. Molecular Biology of the Cell 15: 332-44.

Tiwari S, Italiano JE Jr, Barral DC, Mules EH, Novak EK, Swank RT, Seabra MC & Shivdasani RA (2003). A role for Rab27b in NF-E2-dependent pathways of platelet formation. Blood 102: 3970-9.

Larijani B, Hume AN, Tarafder AK & Seabra MC (2003). Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. Journal of Biological Chemistry 278: 46798-804.

Bahadoran P, Busca R, Chiaverini C, Westbroek W, Lambert J, Bille K, Valony G, Fukuda M, Naeyaert JM, Ortonne JP & Ballotti R (2003). Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome. Journal of Biological Chemistry 278: 11386-92.

Menasche G, Feldmann J, Houdusse A, Desaymard C, Fischer A, Goud B & de Saint Basile G (2003). Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients. Blood 101: 2736-42.

Zhao S, Torii S, Yokota-Hashimoto H, Takeuchi T & Izumi T (2002). Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology 143: 1817-24.

Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T & Izumi T (2002). Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Letters 517: 233-8.

Wu X, Wang F, Rao K, Sellers JR & Hammer JA 3rd. (2002). Rab27a is an essential component of melanosome receptor for myosin Va. Molecular Biology of the Cell 13: 1735-49.

Chen D, Guo J, Miki T, Tachibana M & Gahl WA (1997). Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. Biochemical and Molecular Medicine 60: 27-37.