PSD 93 (chapsin110, DLG 2)

A component of postsynaptic densities in central synapses

General Information

PSD 93 (postsynaptic density protein of 93 kDa, also called chapsin 110 and DLG 2) belongs to the PSD 95 family containing a modular structure with three PDZ-, one SH3- and a guanylate kinase-like domain. It is a component of postsynaptic densities in central synapses.
PSD 93 is expressed in discrete neuronal populations as well as in specific non-neuronal cells. It exhibits complex molecular diversity attributable to tissue-specific alternative splicing. PSD 93, like PSD 95, binds to NMDA receptors and to the neuronal nitric oxide synthase (NOS).
PSD 93 and PSD 95 can heteromultimerize with each other and are recruited into the same NMDA receptor and K+ channel clusters. PSD 93, however, is unique among PSD 95 family members in its expression in Purkinje neuron cell bodies and dendrites.