Profilins

Regulators of the microfilament network

General Information

Profilins are small proteins (14-17 kDa) which are involved in the regulation of the cellular microfilament system. They are associated with highly dynamic microfilament structures present at cellular membranes. Profilins have been found together with lamellipodia, focal adhesions, surface ruffles and on intracellular vesicles and have been shown to interact with different cytoskeleton proteins like actin, gephyrin and the Arp 2/3 complex. Recently a tumor suppression activity has been described for profilin.