PACSIN 1

A dynamin 1 associated protein

General Information

This protein has been described as PACSIN 1 (for PKC and CK2 substrate in neurons) and syndapin 1 (synaptic, dynamin-associated protein I). It is a multidomain phospho-protein that interacts via its SH3 domain with dynamin 1, synaptojanin, synapsin and N-WASP. Since N-WASP is an activator of the Arp2/3 complex, syndapin may link membrane trafficking and the actin cytoskeleton.
Up to now, 3 isoforms have been described. Syndapin 1 shows a neuronal, syndapin 3 a muscular and syndapin 2 an ubiquitous expression profile.