Proton ATPase (116 kDa subunit)

Largest subunit of the vacuolar proton pump in synaptic vesicles and coated vesicles

References SySy proton ATPase antibodies

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, Uchiyama Y, Westaway D, Cuervo AM & Nixon RA (2010). Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141: 1146-58. WB, ICC

Astarie-Dequeker C, Le Guyader L, Malaga W, Seaphanh FK, Chalut C, Lopez A & Guilhot C (2009). Phthiocerol dimycocerosates of M. tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids. PLoS Pathogens 5: e1000289. ICC

Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U & Ahnert-Hilger G (2006). Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. Journal of Biological Chemistry 281: 15671-9. WB

Seong E, Wainer BH, Hughes ED, Saunders TL, Burmeister M & Faundez V (2005). Genetic analysis of the neuronal and ubiquitous AP-3 adaptor complexes reveals divergent functions in brain. Molecular Biology of the Cell 16: 128-40. WB

Bohnert S & Schiavo G (2005). Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation. Journal of Biological Chemistry 280: 42336-44. WB, ICC

Li G, Yang Q, Alexander EA & Schwartz JH (2005). Syntaxin 1A has a specific binding site in the H3 domain that is critical for targeting of H+-ATPase to apical membrane of renal epithelial cells. American Journal of Physiology. Cell Physiology 289: C665-72. WB

Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A & Faundez V (2004). The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. Molecular Biology of the Cell 15: 575-87-7. WB

Li G, Alexander EA & Schwartz JH (2003). Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. Journal of Biological Chemistry 278: 19791-7. WB

General references proton ATPase

Südhof TC (1995). The synaptic vesicle cycle: a cascade of protein- protein interactions. Nature 375: 645-53. Review

Jahn R & Südhof TC (1994). Synaptic vesicles and exocytosis. Annual Review of Neuroscience 17: 219-46. Review, no abstract available

Perin MS, Fried VA, Stone DK, Xie XS & Sudhof TC (1991). Structure of the 116-kDa polypeptide of the clathrin-coated vesicle/synaptic vesicle proton pump. Journal of Biological Chemistry 266: 3877-81.