Arp 2/3 complex

A seven protein complex required for actin nucleation

References SySy Arp 2/3 complex antibodies

Lladó A, Timpson P, Vilà de Muga S, Moretó J, Pol A, Grewal T, Daly RJ, Enrich C & Tebar F (2008). Protein kinase Cδ and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin. Molecular Biology of the Cell 19: 17-29. Clone 323H3; ICC

Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. Clones 24A6 and 323H3; WB

Steffen A, Faix J, Resch GP, Linkner J, Wehland J, Small JV, Rottner K & Stradal TE (2006). Filopodia Formation in the Absence of Functional WAVE- and Arp2/3-Complexes. Molecular Biology of the Cell 17: 2581-91. Clones 24A6 and 323H3; WB

Dubois T, Paleotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M & Chavrier P (2005). Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics. Nature Cell Biology 7: 353-64.

General references Arp 2/3 complex

Winder SJ (2003). Structural insights into actin-binding, branching and bundling proteins. Current Opinion in Cell Biology 15: 14-22.

Pollard TD & Borisy GG (2003). Cellular motility driven by assembly and disassembly of actin filaments. Cell 112: 453-65.

Pollard TD & Beltzner CC (2002). Structure and function of the Arp 2/3 complex. Current Opinion in Structural Biology 12: 768-74.

Gournier H, Goley ED, Niederstrasser H, Trinh T & Welch MD (2001). Reconstitution of human Arp 2/3 complex reveals critical roles of individual subunits in complex structure and activity. Molecular Cell 8: 1041-52.