Munc 18 (rb-sec1, n-sec1)

Peripheral membrane protein involved in vesicle docking and fusion

References SySy Munc 18 antibodies

Ohno Y, Ishihara S, Terada R, Kikuta M, Sofue N, Kawai Y, Serikawa T & Sasa M (2009). Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Biochemical and Biophysical Research Communications 390: 415-20. 116 002; WB

Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T (2005). Granuphilin molecularly docks insulin granules to the fusion machinery. Journal of Cell Biology 171: 99-109. 116 002; WB

Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA & Bredt DS (2005). Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. Journal of Cell Biology 170: 1127-34. 116 002; WB

Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H & Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. Journal of Clinical Investigation 115: 388-96. 116 002; IP

Zhang Q, Pangrsic T, Kreft M, Krzan M, Li N, Sul JY, Halassa M, Van Bockstaele E, Zorec R & Haydon PG (2004). Fusion-related release of glutamate from astrocytes. Journal of Biological Chemistry 279: 12724-33. 116 002; ICC

Houng A, Polgar J & Reed GL (2003). Munc18-syntaxin complexes and exocytosis in human platelets. Journal of Biological Chemistry 278: 19627-33.

Varoqueaux F, Sigler A, Rhee JS, Brose N, Enk C, Reim K & Rosenmund C (2002). Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proceedings of the National Academy of Sciences U.S.A 99: 9037-42.

Zhang W, Efanov A, Yang S-N, Fried G, Kölare S, Brown H, Zaitsev S, Berggren P-O & Meister B (2000). Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic β-cell. Journal of Biological Chemistry 275: 41521-7. 116 002; IP, IHC

General references Munc 18

Fukuda M, Imai A, Nashida T & Shimomura H (2005). Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner. Journal of Biological Chemistry 280: 39175-84.

Martin-Verdeaux S, Pombo I, Iannascoli B, Roa M, Varin-Blank N, Rivera J & Blank U (2003). Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. Journal of Cell Science 116(Pt2): 325-34.

Riento K, Kauppi M, Keranen S & Olkkonen VM (2000). Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. Journal of Biological Chemistry 275: 13476-83.

Tellam JT, McIntosh S & James DE (1995). Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. Journal of Biological Chemistry 270: 5857-63.

Hata Y & Südhof TC (1995). A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Journal of Biological Chemistry 270: 13022-8.

Pevsner J, Hsu SC & Scheller RH (1994). n-Sec1: a neural-specific syntaxin-binding protein. Proceedings of the National Academy of Sciences USA 91: 1445-9.

Garcia EP, Gatti E, Butler M, Burton J & De Camilli P (1994). A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proceedings of the National Academy of Sciences USA 91: 2003-7.

Hata Y, Slaughter CA & Südhof TC (1993). Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366: 347-51.