Munc 18 (rb-sec1, n-sec1)

Peripheral membrane protein involved in vesicle docking and fusion

References SySy Munc 18 antibodies

Jorgacevski J, Potokar M, Grilc S, Kreft M, Liu W, Barclay JW, Bückers J, Medda R, Hell SW, Parpura V, Burgoyne RD & Zorec R (2011). Munc18-1 Tuning of Vesicle Merger and Fusion Pore Properties. Journal of Neuroscience 31: 9055-66. Munc 18-1 rabbit antiserum; ICC

Wiseman DA, Kalwat MA & Thurmond DC (2011). Stimulus-induced S-nitrosylation of syntaxin 4 impacts insulin granule exocytosis. Journal of Biological Chemistry 286: 16344-54. clone 131.1; WB in supplement

Hellwig S, Hack I, Kowalski J, Brunne B, Jarowyj J, Unger A, Bock HH, Junghans D & Frotscher M (2011). Role for Reelin in neurotransmitter release. Journal of Neuroscience 31: 2352-60. Munc 18-1 rabbit antiserum; WB

Ohno Y, Ishihara S, Terada R, Kikuta M, Sofue N, Kawai Y, Serikawa T & Sasa M (2009). Preferential increase in the hippocampal synaptic vesicle protein 2A (SV2A) by pentylenetetrazole kindling. Biochemical and Biophysical Research Communications 390: 415-20. 116 002; WB

Gomi H, Mizutani S, Kasai K, Itohara S, Izumi T (2005). Granuphilin molecularly docks insulin granules to the fusion machinery. Journal of Cell Biology 171: 99-109. 116 002; WB

Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA & Bredt DS (2005). Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. Journal of Cell Biology 170: 1127-34. 116 002; WB

Kasai K, Ohara-Imaizumi M, Takahashi N, Mizutani S, Zhao S, Kikuta T, Kasai H, Nagamatsu S, Gomi H & Izumi T (2005). Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation. Journal of Clinical Investigation 115: 388-96. 116 002; IP

Zhang Q, Pangrsic T, Kreft M, Krzan M, Li N, Sul JY, Halassa M, Van Bockstaele E, Zorec R & Haydon PG (2004). Fusion-related release of glutamate from astrocytes. Journal of Biological Chemistry 279: 12724-33. 116 002; ICC

Houng A, Polgar J & Reed GL (2003). Munc18-syntaxin complexes and exocytosis in human platelets. Journal of Biological Chemistry 278: 19627-33.

Varoqueaux F, Sigler A, Rhee JS, Brose N, Enk C, Reim K & Rosenmund C (2002). Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proceedings of the National Academy of Sciences U.S.A 99: 9037-42.

Zhang W, Efanov A, Yang S-N, Fried G, Kölare S, Brown H, Zaitsev S, Berggren P-O & Meister B (2000). Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic β-cell. Journal of Biological Chemistry 275: 41521-7. 116 002; IP, IHC

General references Munc 18

Fukuda M, Imai A, Nashida T & Shimomura H (2005). Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner. Journal of Biological Chemistry 280: 39175-84.

Martin-Verdeaux S, Pombo I, Iannascoli B, Roa M, Varin-Blank N, Rivera J & Blank U (2003). Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. Journal of Cell Science 116(Pt2): 325-34.

Riento K, Kauppi M, Keranen S & Olkkonen VM (2000). Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells. Journal of Biological Chemistry 275: 13476-83.

Tellam JT, McIntosh S & James DE (1995). Molecular identification of two novel Munc-18 isoforms expressed in non-neuronal tissues. Journal of Biological Chemistry 270: 5857-63.

Hata Y & Südhof TC (1995). A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. Journal of Biological Chemistry 270: 13022-8.

Pevsner J, Hsu SC & Scheller RH (1994). n-Sec1: a neural-specific syntaxin-binding protein. Proceedings of the National Academy of Sciences USA 91: 1445-9.

Garcia EP, Gatti E, Butler M, Burton J & De Camilli P (1994). A rat brain Sec1 homologue related to Rop and UNC18 interacts with syntaxin. Proceedings of the National Academy of Sciences USA 91: 2003-7.

Hata Y, Slaughter CA & Südhof TC (1993). Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366: 347-51.