Munc 13
Mammalian homologues of the C. elegans unc-13 gene essential for exocytosis
References SySy Munc 13 antibodies
Lazarevic V, Schöne C, Heine M, Gundelfinger ED & Fejtova A (2011). Extensive remodeling of the presynaptic cytomatrix upon homeostatic adaptation to network activity silencing. Journal of Neuroscience 31: 10189-200. Munc 13-1 rabbit antibody; WB, ICCMartín R, Durroux T, Ciruela F, Torres M, Pin JP & Sánchez-Prieto J (2010). The metabotropic glutamate receptor mGlu7 activates phospholipase C, translocates munc-13-1 protein, and potentiates glutamate release at cerebrocortical nerve terminals. Journal of Biological Chemistry: 285: 17907-17. clone 266B1; IP
Lanore F, Blanchet C, Fejtova A, Pinheiro P, Richter K, Balschun D, Gundelfinger E & Mulle C (2010). Impaired development of hippocampal mossy fibre synapses in mouse mutants for the presynaptic scaffold protein Bassoon. Journal of Physiology 588(Pt12): 2133-45. rabbit antibody; IHC
Rinetti GV & Schweizer FE (2010). Ubiquitination acutely regulates presynaptic neurotransmitter release in mammalian neurons. Journal of Neuroscience 30: 3157-66. rabbit antiserum; WB
Jiang X, Litkowski PE, Taylor AA, Lin Y, Snider BJ & Moulder KL (2010). A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing. Journal of Neuroscience 30: 1798-1809. rabbit antibody; ICC
Fejtova A, Davydova D, Bischof F, Lazarevic V, Altrock WD, Romorini S, Schöne C, Zuschratter W, Kreutz MR, Garner CC, Ziv NE & Gundelfinger ED (2009). Dynein light chain regulates axonal trafficking and synaptic levels of Bassoon. Journal of Cell Biology 185: 341-55. rabbit antibody; ICC
Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED & Garner CC (2008). Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. Journal of Cell Biology 181: 831-46. rabbit antibody; ICC
Spiwoks-Becker I, Maus C, tom Dieck S, Fejtová A, Engel L, Wolloscheck T, Wolfrum U, Vollrath L & Spessert R (2008). Active zone proteins are dynamically associated with synaptic ribbons in rat pinealocytes. Cell and Tissue Research 333: 185-95. rabbit antibody; IHC
Leal-Ortiz S, Waites CL, Terry-Lorenzo R, Zamorano P, Gundelfinger ED & Garner CC (2008). Piccolo modulation of Synapsin1a dynamics regulates synaptic vesicle exocytosis. Journal of Cell Biology 181: 831-46. rabbit antibody; ICC
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, Rammner B, Gräter F, Hub JS, De Groot BL, Mieskes G, Moriyama Y, Klingauf J, Grubmüller H, Heuser J, Wieland F & Jahn R (2006). Molecular anatomy of a trafficking organelle. Cell 127: 831-46. Clone 266B1; WB in supplement
Hu L, Chen Y, Evers S & Shen Y (2005). Expression of fragile X mental retardation-1 gene with nuclear export signal mutation changes the expression profiling of mouse cerebella immortal neuronal cell. Proteomics 5: 3979-90.
Varoqueaux F, Sigler A, Rhee JS, Brose N, Enk C, Reim K & Rosenmund C (2002). Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proceedings of the National Academy of Sciences USA 99: 9037-42.
General references Munc 13
Goldenberg NM & Silverman M (2009). Rab34 and its effector munc13-2 constitute a new pathway modulating protein secretion in the cellular response to hyperglycemia. American Journal of Physiology 297: C1053-8.Zhu Y, Ehre C, Abdullah LH, Sheehan JK, Roy M, Evans CM, Dickey BF & Davis CW (2008). Munc13-2-/- baseline secretion defect reveals source of oligomeric mucins in mouse airways. Journal of Physiology 586: 1977-92.
Yang CB, Kiser PJ, Zheng YT, Varoqueaux F & Mower GD (2007). Bidirectional regulation of Munc13-3 protein expression by age and dark rearing during the critical period in mouse visual cortex. Neuroscience 150: 603-8.
Sheu L, Pasyk EA, Ji J, Huang X, Gao X, Varoqueaux F, Brose N & Gaisano HY (2003). Regulation of insulin exocytosis by Munc13-1. Journal of Biological Chemistry 278: 27556-63.
Ohtsuka T, Takao-Rikitsu E, Inoue E, Inoue M, Takeuchi M, Matsubara K, Deguchi-Tawarada M, Satoh K, Morimoto K, Nakanishi H & Takai Y (2002). Cast: a novel protein of the cytomatrix at the active zone of synapses that forms a ternary complex with RIM1 and munc13-1. Journal of Cell Biology 158: 577-90.
Yang CB, Zheng YT, Li GY & Mower GD (2002). Identification of Munc13-3 as a candidate gene for critical-period neuroplasticity in visual cortex. Journal of Neuroscience 22: 8614-8.
Augustin I, Korte S, Rickmann M, Kretzschmar HA, Südhof TC, Herms JW & Brose N (2001). The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice. Journal of Neuroscience 21: 10-7.
Ashery U, Varoqueaux F, Voets T, Betz A, Thakur P, Koch H, Neher E, Brose N & Rettig J (2000). Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells. EMBO Journal 19: 3586-96.
Brose N, Rosenmund C & Rettig J (2000). Regulation of transmitter release by Unc-13 and its homologues. Current Opinion in Neurobiology 10: 303-11.
Augustin I, Betz A, Herrmann C, Jo T & Brose N (1999). Differential expression of two novel Munc13 proteins in rat brain. Biochemical Journal 337 (Pt3): 363-71.
Betz A, Okamoto M, Benseler F & Brose N (1997). Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. Journal of Biological Chemistry 272: 2520-6.
Südhof TC (1995). The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature 375: 645-53. Review
Brose N, Hofmann K, Hata Y & Sudhof TC (1995). Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins. Journal of Biological Chemistry 270: 25273-80.
Jahn R & Südhof TC (1994). Synaptic vesicles and exocytosis. Annual Review of Neuroscience 17: 219-46. Review, no abstract available
